Sort   by:  
 Page size 
TranscriptomicsChromatin immunoprecipitation of transcription factor binding in yeast cells perturbed with methyl-methanesulfonate
Genome-wide promoter-binding analysis of transcription factors in S.cerevisiae cells perturbed with 0.03% methyl-methanesulfonate for 60 minutes
ORGANISM(S): Saccharomyces cerevisiae 
2006-05-19 | E-TABM-92 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast transcription factor deletion strains perturbed with methyl-methanesulfonate
Gene expression profiles of transcription factor deletion strains (S.cerevisiae) perturbed with 0.03% methyl-methanesulfonate for 60 minutes
ORGANISM(S): Saccharomyces cerevisiae 
2006-05-19 | E-TABM-93 | biostudies-arrayexpress
no omics definedChIP-chip by array of yeast to monitor mobilization of transcriptional regulators in response to methyl methanesulfonate and heat shock
Monitoring mobilization of transcriptional regulators in response to methyl methanesulfonate and heat shock using ChIP-chip
ORGANISM(S): Saccharomyces cerevisiae 
2010-11-10 | E-MEXP-2614 | biostudies-arrayexpress
TranscriptomicsRNA-seq of OPI1 knockout yeast cells and the effect of methyl methanesulfonate (MMS) treatment relative to wild-type yeast cells with or without MMS treatment
Methyl methanesulfonate (MMS) is a DNA damage agent that induces the DNA damage response (DDR). Recent findings in the literature suggest a role for phosphatidylinositol signaling in regulating the DDR. In budding yeast, inositol biosynthesis is fine-tuned by the transcriptional repressor Opi1. We c...
ORGANISM(S): Saccharomyces cerevisiae 
2023-07-05 | E-MTAB-13057 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae TFIIH mutants treated with methyl methanesulfonate
Purpose of profiling experiment was to examine effects of a mutation of a subunit of TFIIH, ssl1p, which has ubiquitin ligase activity.,The whole complex has previously been shown to have both kinase and helicase activities. We wanted to see if 1) there were,general transcriptional defects with the...
ORGANISM(S): Saccharomyces cerevisiae 
2007-07-08 | E-GEOD-2343 | biostudies-arrayexpress
TranscriptomicsDNA damage checkpoint kinases regulate a global network of transcription factors
DNA damage results in the activation of checkpoint kinases, which phosphorylate downstream effectors that inhibit the cell cycle, activate DNA repair, and cause widespread changes in transcription. However, the specific connections between the checkpoint kinases and downstream transcription factors ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-31 | E-GEOD-40351 | biostudies-arrayexpress
ProteomicsIdentifying proteins altered during Methyl methanesulfonate treatment
Humans are exposed to a wide range of exogenous and endogenous alkylating agents, including agents frequently used as cytostatic drugs in cancer treatment (Drablos, Feyzi et al. 2004). Alkylating agents are mutagenic and cytotoxic and the major body of research has focused on their effects upon DNA....
ORGANISM(S): Homo sapiens (Human) 
2021-08-30 | PXD003549 | Pride
Proteomics Methyl methanesulfonate Prbitrap Silac Label-free Dna damage Quantification 
TranscriptomicsCharacterization of Formaldehyde's Genotoxic Mode of Action by Gene Expression Analysis in TK6 Cells
Gene expression analysis has been established as a tool for the characterization of genotoxic mechanisms of chemical mutagens. This approach has been shown to differentiate between DNA reactive genotoxins and non-DNA reactive or indirectly-acting genotoxins. In this context, it has been suggested th...
ORGANISM(S): Homo sapiens 
2013-05-13 | E-GEOD-41296 | biostudies-arrayexpress
TranscriptomicsChIP-chip from HCT116 cells treated with MMS and LNCaP cells with ATF3
Maintenance of genetic integrity is essential for survival of all organisms. Activating transcription factor 3 (ATF3) is a member of the c-AMP response element binding (CREB)/ATF family of transcription factors, and is highly inducible by various stress conditions including DNA damage. However, dow...
ORGANISM(S): Homo sapiens 
2010-10-01 | E-GEOD-18457 | biostudies-arrayexpress
TranscriptomicsTranslational and transcriptional responses of fission yeast to MMS
Ribosome profiling was used to investigate how Schizosaccharomcyes pombe cells modulate gene expression in response to methyl methanesulfonate (MMS)
ORGANISM(S): Schizosaccharomyces pombe 
2020-11-18 | E-MTAB-8745 | biostudies-arrayexpress
Sort   by:  
 Page size