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ProteomicsCRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neurodegeneration
Accumulation of aggregated and misfolded proteins, leading to endoplasmic reticulum stress and activation of the unfolded protein response, is a hallmark of several neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. Genetic screens are powerful tools that are proving invalua...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD038395 | Pride
Cortical neurons Kat2b L-moses Endoplasmic reticulum (er) stress Acetylome 
ProteomicsGenome-Wide CRISPR/Cas9 Screen shows that inhibiting GET4 is neuroprotective and increases mitochondrial-endoplasmic reticulum contact sites
Organelles form contacts between each other allowing for transfer of molecules and signals. Mitochondria-ER Contact sites (MERCS) are lengths of the Mitochondria and ER membrane which come together but do not fuse. They have been implicated in many diseases, including neurodegenerative, metabolic, a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042710 | Pride
Mitochondrial-er contact site Neuroprotection Ip-mass spectrometry 
GenomicsChIP-seq analysis of Foxa2 binding sites in midbrain dopaminergic progenitors
Embryonic stem (ES) cells were differentiated in culture to midbrain dopaminergic (mDA) progenitors and subjected to ChIP-seq analysis to resolve genome-wide binding sites of forkhead box protein A2 (Foxa2). Foxa2 was found to directly regulate multiple lineage pathways to specify midbrain dopaminer...
ORGANISM(S): Mus musculus 
2012-07-01 | E-MTAB-1137 | biostudies-arrayexpress
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