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MetabolomicsEffect of L-carnitine administration on lipid and metabolite content in sheep infraspinatus muscle after tendon release
Metabolites and lipid species were measured using ultrahigh performance lipid chromatography – tandem mass spectrometry in biopsies of infraspinatus muscle after 2 weeks of tendon release in the operated and contralateral muscle. A group of animals received oral treatment with L-carnitine.
2020-07-20 | MTBLS1490 | MetaboLights
ProteomicsNeprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides
Muscle contraction depends on strictly controlled Ca2+ transients within myocytes. A major player maintaining these transients is the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase, SERCA. Activity of SERCA is regulated by binding of micropeptides and impaired expression or function of these peptide...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-06-01 | PXD027738 | Pride
Neprilysin Calcium homeostasis Metallopeptidase Micropeptides Serca Heart physiology Drosophila melanogaster 
TranscriptomicsWT and irf3-/- macrophage response to WT L. monocytogenes
Transcriptional profiling of WT and irf3-/- macrophages infected with WT L. monocytogenes for 180 minutes Keywords: Cell type comparison. Experiment in different genetic backgrounds, with WT bacteria. Multiple biological replicates (see array names), with one replicate per array.
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-8101 | biostudies-arrayexpress
TranscriptomicsPrimary macrophage response to L. monocytogenes and bacteria-derived ligands
Transcriptional profiling of macrophages (of various genetic backgrounds) infected with L. monocytogenes or transfected with purified ligands Keywords: Timecourse, cell type comparison, bacteria strain comparison, drug comparison, ligand comparison. Timecourse experiment in different genetic backgro...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-8104 | biostudies-arrayexpress
TranscriptomicsWT and myd88-/- macrophage response to WT and hly- L. monocytogenes
Transcriptional profiling of WT and myd88-/- macrophages infected with WT and hly- L. monocytogenes for 30, 60, 120, or 180 minutes Keywords: Timecourse, cell type comparison, bacteria strain comparison. Timecourse experiment in different genetic backgrounds, with both WT and mutant bacteria. Multi...
ORGANISM(S): Mus musculus 
2007-12-31 | E-GEOD-8100 | biostudies-arrayexpress
TranscriptomicsWT macrophage response to WT L. monocytogenes, with or without CAPE treatment
Transcriptional profiling of WT macrophages infected with WT L. monocytogenes for 180 minutes, with or without CAPE treatment Keywords: Drug comparison. Experiment in WT background, with WT bacteria, with or without drug treatment. Multiple biological replicates (see array names), with one replicat...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-8102 | biostudies-arrayexpress
TranscriptomicsTranscript profiles of the flowering period Panax ginseng C.A. Meyer root and analysis the gene function
Panax ginseng C.A. Meyer is one of the most popular medicinal herbs. In order to research the genes that related to the flowering period of ginseng, and find out the antifungal proteins and transcription factors that combat various biotic and abiotic stress, a cDNA sample was prepared from the flowe...
ORGANISM(S): Panax ginseng 
2014-07-25 | E-MTAB-1239 | biostudies-arrayexpress
MetabolomicsPREDICT: untargeted metabolomic profiling in a Brassica napus (canola) breeding population by GC-MS

Genome-wide association studies (GWAS) identified thousands of genetic loci associated with complex plant traits, including many traits of agronomical importance. However, functional interpretation of GWAS results remains challenging because of large candidate regions due to linkage disequilibriu...

2023-11-20 | MTBLS8056 | MetaboLights
ModelsKosinsky2018 - Radiation and PD-(L)1 treatment combinations
This is a quantitative systems pharmacology (QSP) model that describes key elements of the cancer immunity cycle and the tumor microenvironment, tumor growth, as well as dose-exposure-target modulation features. The model describes the synergistic kinetic effects underlying immune cell interactions ...
2024-09-02 | BIOMD0000000863 | BioModels
Immuno-oncology 
ModelsMeyer1991_CalciumSpike_ICC
This a model from the article: Calcium spiking. Meyer T, Stryer L Annu Rev Biophys Biophys Chem1991:20:153-74 1867714, Abstract: No Abstract Available The IP3-Ca2+ Crosscoupling Model (ICC) is reviewed by Meyer and Stryer in 1991, orig...
2024-09-02 | BIOMD0000000224 | BioModels
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