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ProteomicsProteomic identification of MHC class I-associated peptidome derived from non-obese diabetic mouse thymus and pancreas
The peptides repertoire presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules, referred to as the MHC I-associated peptidome (MIP), regulates all critical events that occur during the lifetime of CD8+ T cells. The MIP presented by thymic antigen presenting cells (APCs...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031966 | Pride
Pancreas Lc-ms/ ms Nod mouse Mhc class i-associated peptidome T1d Cd8+ t-cell. Thymus 
ProteomicsIntegrative MHC-I peptidome quantitation with isobaric tagging mass spectrometry
Despite the appreciation of CD8+ T cell anti-tumor immune responses towards improvement patient outcomes, the MHC-I peptides that facilitate the response are poorly described. Alternatively, whether cancer therapies alter the MHC-I peptide repertoire has not been fully assessed due to the lack of qu...
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD011464 | Pride
Mhc-i peptidomics Source proteome 
ProteomicsIntegrative MHC-I peptidome quantitation with isobaric tagging mass spectrometry
Despite the appreciation of CD8+ T cell anti-tumor immune responses towards improvement patient outcomes, the MHC-I peptides that facilitate the response are poorly described. Alternatively, whether cancer therapies alter the MHC-I peptide repertoire has not been fully assessed due to the lack of qu...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-05 | PXD011444 | Pride
Source proteins Mhc-i peptides 
ProteomicsMHC-I peptidome analysis of human foreskin fibroblasts
Ribosome profiling (Ribo-seq) recently revealed the expression of thousands of short open reading frames (sORFs) in eukaryotic cells. They encode for a class of instable peptides, which evade experimental validation by whole-proteome mass spectrometry. Here, we show that computational elimination of...
ORGANISM(S): Homo sapiens (Human) 
2018-04-05 | PXD007203 | Pride
Human Hff Peptidome Mhc-i 
ProteomicsDigging deeper into the HLA peptidome – Characterization of the post-translationally modified peptides
Peptides displayed by MHC molecules on a cell’s surface, referred to as its immunopeptidome, play an important role in the adaptive the immune response. Antigen processing for MHC class I presentation is a ubiquitous pathway present in all nucleated cells which generate and present peptides of both ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD024562 | Pride
Spliced peptides Immunopeptidome Post-translational modifications Mhc class i Mhc binding motifs 
ProteomicsMHC-I peptidome analysis of human cancer cell lines
In this study, we sought to identify naturally presented MHC peptides in 3 human cancer cell lines: A431, Colo668, HuCCT1. Peptides identified were 8-15 amino acid long with the majority between 8 to 11 amino acids which match known properties of MHC-I presented peptides.
ORGANISM(S): Homo sapiens (Human) 
2022-05-09 | PXD033685 | Pride
Hla-i Lc-ms/ms 
ProteomicsHuman NDMM MHC-I immunopeptidome mass spectrometry
To assess the contribution of ribosome profiling-detected nuORFs in NDMM to the MHC-I immunopeptidome and their potential for generating neoantigens, we obtained MHC-I immunopeptidome mass spectrometry (MS/MS) spectra from three patients with NDMM.
ORGANISM(S): Homo sapiens (Human) 
2025-02-20 | PXD047053 | Pride
Human Ndmm Mhc-i Lc-ms/ms 
ProteomicsMHC-I peptidome analysis of human cancer cell lines
In this study, we sought to identify naturally presented MHC peptides in 8 human cancer cell lines: PANC.1, A.375, SW527, CaSki, PC.3, LNCaP_clone_FGC, MCF.7, and VMRC.LCD. Peptides identified were 8-15 amino acid long with the majority between 8 to 11 amino acids which match known properties of MHC...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022020 | Pride
Hla-i Lc-ms/ms 
UnknownImmune Checkpoint Blockade Augments Changes Within Oncolytic Virus-induced Cancer MHC-I Peptidome, Creating Novel Antitumor CD8 T Cell Reactivities.
Not available
S-EPMC8864471 | biostudies-literature
UnknownDefective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells.
Not available
S-EPMC9024965 | biostudies-literature
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