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ProteomicsImmunopeptidomics of Francisella tularensis LVS infected dendritic cells.
We used immunopeptidomics to identify MHC class II peptides and antigens of the intracellular bacterial pathogen Francisella tularensis. We infected dendritic cells from mouse bone marrow with F. tularensis LVS strain or its dsbA gene mutant strain, isolated peptide-MHC-II complexes, and identified ...
ORGANISM(S): Francisella tularensis subsp. holarctica (strain LVS) Mus musculus (Mouse) 
2026-09-09 | PXD066780 | Pride
Francisella tularensis Immunopeptidomics Antigen presentation Mhc class ii 
ProteomicsUnveiling signaling pathways inducing MHC class II expression in neutrophils
Gram-negative bacillary bacteremia poses a significant threat, ranking among the most severe infectious diseases capable of triggering life-threatening sepsis. Despite the unambiguous involvement of neutrophils in this potentially fatal disease, there are limited data about the molecular signaling m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095939 | MassIVE
ProteomicsDeciphering and predicting CD4+ T cell immunodominance of Influenza virus hemagglutinin
The importance of CD4+ T helper (Th) cells is well appreciated in view of their essential role in the elicitation of antibody and cytotoxic T cell responses. However, the mechanisms that determine the selection of immunodominant epitopes within complex protein antigens remain elusive. Here, we used ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Influenza A virus (A/California/07-00002/2009(H1N1)) 
2020-06-29 | PXD018151 | Pride
Peptidomics Influenza Mhc-ii Modc Ebv-b Antigen presentation Human Hemagglutinin 
ProteomicsA single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients
Natalizumab (NZM), a humanized monoclonal IgG4 antibody to α4 integrins, is used to treat patients with relapsing-remitting multiple sclerosis (MS), but in about 6% of the cases persistent neutralizing anti-drug antibodies (ADAs) are induced leading to therapy discontinuation. To understand the basi...
ORGANISM(S): Homo sapiens (Human) 
2019-10-10 | PXD013599 | Pride
Antibody therapy Mhc-ii peptidomics Multiple sclerosis Human 
ProteomicsDNA Damage in Macrophages Drives Immune Autoreactivity via Nuclear Antigen Presentation
Aging and DNA damage increase the risk of chronic inflammation and autoimmunity, yet their molecular underpinnings remain unclear. Here, we uncover a DNA damage-driven mechanism in macrophages that triggers immune autoreactivity. Using Er1Lyz2/- animals with a macrophage-specific DNA repair defect i...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-02 | PXD058775 | Pride
Dna damage  immunosenescence  antigen presentation  autophagy  immunopeptidomics  autoimmune responses  t-cell responses 
ProteomicsMHC Peptidomics: HLA-B*27 vs Mamu-B*08
Indian rhesus macaques are arguably the most reliable animal models in AIDS research. In this species the MHC class I allele Mamu-B*08, among others, is associated with elite control of SIV replication. A similar scenario is observed in humans where the expression of HLA-B*27 or HLA-B*57 has been li...
ORGANISM(S): Homo sapiens (Human) 
2016-10-07 | PXD004964 | Pride
Peptides Hla-b*27 Mhc Hiv Peptidomics Mamu-b*08 Lc-ms/ms Siv 
UnknownIntegral Use of Immunopeptidomics and Immunoinformatics for the Characterization of Antigen Presentation and Rational Identification of BoLA-DR-Presented Peptides and Epitopes.
Not available
S-EPMC8113073 | biostudies-literature
UnknownDeciphering and predicting CD4+ T cell immunodominance of influenza virus hemagglutinin.
Not available
S-EPMC7537397 | biostudies-literature
ProteomicsSensitive and quantitative detection of MHC-I displayed neoepitopes using a semi-automated workflow and TOMAHAQ mass spectrometry
Advances in several key technologies, including MHC peptidomics, has helped fuel our understanding of basic immune regulatory mechanisms and identify T cell receptor targets for the development of immunotherapeutics. Isolating and accurately quantifying MHC-bound peptides from cells and tissues enab...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2020-12-11 | MSV000086582 | MassIVE
ProteomicsFunctional protein composition in femoral glands of sand lizards (Lacerta agilis)
Proteins are ubiquitous macromolecules displaying a vast repertoire of chemical and enzymatic functions making them suitable candidates for chemosignals used in intraspecific communication. Proteins are present in skin gland secretions of vertebrates but their identity, and especially, their functio...
ORGANISM(S): Lacerta Agilis (ncbitaxon:80427) 
2022-02-10 | MSV000088810 | MassIVE
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