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TranscriptomicsThe Mi-2 homolog, Mit1, actively positions nucleosomes within heterochromatic domains to suppress transcription
Nucleosome positioning is both active and passive and regulates access to the genome for replication, transcription and repair. Here we report that Mit1, a subunit of the fission yeast SHREC complex similar to Mi-2/NuRD, regulates transcription at regions of heterochromatin by positioning nucleosome...
ORGANISM(S): Schizosaccharomyces pombe 
2014-04-08 | E-GEOD-46649 | biostudies-arrayexpress
ProteomicsThe Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation
In eukaryotes, trimethylation of lysine 9 on histone H3 (H3K9) is associated with transcriptional silencing of transposable elements (TEs). In drosophila ovaries, this heterochromatic repressive mark is thought to be deposited by SetDB1 on TE genomic loci after the initial recognition of nascent tra...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-07-21 | PXD018749 | Pride
Mep-1 Rpd3 Mi-2 Gtsf1 
TranscriptomicsGenome-wide analysis of gene expression response to MI-2 and z-VRPR-fmk in ABC-DLBCL cell lines
MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo Total RNA was obtained from HBL-1 and TMD8 cell lines subjected to 8 hours treatment with MI-2, z-VRPR-fmk or vehicle.
ORGANISM(S): Homo sapiens 
2012-12-11 | E-GEOD-40003 | biostudies-arrayexpress
GenomicsThe Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation
The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation
PRJNA592901 | ENA
GenomicsMi-2 and E93 coordinate robust cell cycle exit with terminal differentiation through enhancer decommissioning [ATAC-seq]
Mi-2 and E93 coordinate robust cell cycle exit with terminal differentiation through enhancer decommissioning [ATAC-seq]
PRJNA1080622 | ENA
GenomicsMi-2 and E93 coordinate robust cell cycle exit with terminal differentiation through enhancer decommissioning [RNA-seq]
Mi-2 and E93 coordinate robust cell cycle exit with terminal differentiation through enhancer decommissioning [RNA-seq]
PRJNA1080621 | ENA
UnknownExpression of the dermatomyositis autoantigen Mi-2 in regenerating muscle.
Not available
S-EPMC2828900 | biostudies-literature
UnknownUV radiation regulates Mi-2 through protein translation and stability.
Not available
S-EPMC2596409 | biostudies-literature
TranscriptomicsMi-2 and E93 coordinate robust cell cycle exit with terminal differentiation through enhancer decommissioning [RNA-seq]
Many postmitotic tissues coordinate robust cell cycle exit with the progression of terminal differentiation. While the signals involved in initiating cell cycle exit during terminal differentiation for some tissues have been described, less is known about the mechanisms that maintain a stable, non-c...
ORGANISM(S): Drosophila melanogaster 
2024-06-26 | GSE259303 | GEO
GenomicsMi-2 and E93 coordinate robust cell cycle exit with terminal differentiation through enhancer decommissioning [ATAC-seq]
Many postmitotic tissues coordinate robust cell cycle exit with the progression of terminal differentiation. While the signals involved in initiating cell cycle exit during terminal differentiation for some tissues have been described, less is known about the mechanisms that maintain a stable, non-c...
ORGANISM(S): Drosophila melanogaster 
2024-06-26 | GSE259302 | GEO
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