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Proteomics2DG-induced protein glycosylation alterations in colorectal cancer cells CX1 using differential glycosite profiling
A new strategy to compare cellular glycoproteomes, thereby identifying membrane proteins with altered glycan structures and the concerned glycosites. The workflow consists of membrane proteins digestion followed by lectin-based isolation of glycopeptides and their fractionation. Since alterations in...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024770 | Pride
Glycoproteomics Glycopeptide 2-deoxy-glucose Glycosite Colorectal cancer 
ProteomicsSILAC-based proteomic profiling of the human colon cancer cell line LS 180 in response to exogenous galectin-4
Galectins constitute a family of ß-galactoside binding proteins that translate sugar-encoded signals of cell surface glycoconjugates into biological effects. The expression pattern of different human galectins changes during tissue development and is altered at sites of inflammation and tumor. Galec...
ORGANISM(S): Homo sapiens (Human) 
2016-12-23 | PXD003489 | Pride
Human Lc-msms Colon cancer Silac Ls 180 Galectin-4 
ProteomicsCombining recombinase-mediated cassette exchange strategy with quantitative proteomic and phosphoproteomic analyses to inspect intracellular functions of the tumor supressor galectin-4 in colorectal cancer cells.
In order to systematically explore Galectin-4 function in CRC we established a CRC cell line where Gal4 expression can be regulated via doxycycline (dox)-inducible expression of a single copy wildtype LGALS4 transgene generated by recombinase-mediated cassette exchange (RMCE). Using this model and a...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD032902 | Pride
Galectin Colorectal cancer 
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