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ProteomicsMultivalent lipid targeting by the calcium-independent C2A domain of Slp-4/granuphilin
Synaptotagmin-like protein 4 (Slp-4), also known as granuphilin, is a Rab effector responsible for docking insulin secretory vesicles to the plasma membrane prior to exocytosis. Slp-4 binds vesicular Rab proteins via an N-terminal Slp homology (SHD) domain, interacts with plasma membrane SNARE comp...
ORGANISM(S): Homo sapiens (Human) 
2020-12-08 | PXD021393 | Pride
Granuphilin Intact protein Phosphogluconate Lcms 
UnknownNivolumab and brentuximab vedotin with or without bendamustine for R/R Hodgkin lymphoma in children, adolescents, and young adults.
Not available
S-EPMC10646780 | biostudies-literature
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
ProteomicsQuantifying Competition Among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism
Mitochondrial dysfunction is one of many key factors in the etiology of alcoholic liver disease (ALD). Lysine acetylation is known to regulate numerous mitochondrial metabolic pathways and recent reports demonstrate that alcohol-induced protein acylation negatively impacts these processes. To identi...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-23 | PXD012089 | Pride
Ethanol metabolism Succinylation Mitochondira Acetylation Acylation 
ProteomicsQuantifying Protein Acetylation in Diabetic Nephropathy from FFPE Explants
Background: Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus and a leading cause of chronic kidney disease and end stage renal disease. One potential mechanism underlying cellular dysfunction contributing to kidney disease is aberrant post-translational modifications, suc...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD041884 | Pride
Proteomics Formalin-fixed paraffin-embedded tissue Mass spectrometry Kidney disease Acetylation Diabetes 
UnknownAutomated Adaptive Absolute Binding Free Energy Calculations.
Not available
S-EPMC11428140 | biostudies-literature
UnknownComparison of Receptor-Ligand Restraint Schemes for Alchemical Absolute Binding Free Energy Calculations.
Not available
S-EPMC10308817 | biostudies-literature
ProteomicsAcetylation changes in NQO1 overexpression in Mouse Skeletal Mucscle
In this manuscript we have explored the role of both Nrf2 and NQO1 in protection against diet-induced metabolic syndrome and demonstrate that both Nrf2 and NQO1 provide protection against HFD-induced adverse phenotypes in a mouse model
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015070 | Pride
Nqo1 Mouse Metabolic syndrome Quantitation Acetylomics Skeletal muscle 
ProteomicsVariable Thresholds for Phosphorylation Targets of the ERK Signaling Pathway
Cell fates regulated by ERK/MAP kinases respond to different thresholds of signaling strength. In mammalian cells, conditions that activate ERK to submaximal levels are sufficient for proliferation, survival and transformation, while stimuli that activate ERK to very high levels often lead to cell d...
ORGANISM(S): Homo Sapiens 
2026-02-25 | PXD070673 | panorama
UnknownImpact of centre volume, surgeon volume, surgeon experience and geographic location on reoperation after intramedullary nailing of tibial shaft fractures
Not available
S-EPMC8410470 | biostudies-literature
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