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UnknownNonstructural Protein L* Species Specificity Supports a Mouse Origin for Vilyuisk Human Encephalitis Virus.
Not available
S-EPMC5487572 | biostudies-literature
UnknownEvasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase L.
Not available
S-EPMC3694852 | biostudies-literature
UnknownA novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.
Not available
S-EPMC5927464 | biostudies-literature
ProteomicsCardioviruses’ leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic
Proteins from unrelated pathogens, including some RNA or DNA viruses and bacteria can recruit and activate cellular p90-ribosomal protein S6 kinases (RSKs) through a common linear motif. Data suggested a model where pathogens' proteins act to dock the recruited RSKs toward specific substrates, which...
ORGANISM(S): Homo sapiens (Human) 
2022-12-08 | PXD034604 | Pride
P90 ribosomal s6 kinases Picornavirus Nucleocytoplasmic traffic Rsk Cardiovirus Phosphorylation Yopm Nucleoporins Linear motifs 
ProteomicsCardiovirus-Mediated PKR Inhibition Results from Nucleocytoplasmic Trafficking Disruption
Protein kinase R (PKR) is a key antiviral kinase activated by binding double-stranded RNA (dsRNA) produced during viral replication. Upon activation, PKR phosphorylates eIF2α, leading to the inhibition of translation and viral replication. However, many viruses have evolved mechanisms to counteract ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD066206 | Pride
Nucleocytoplasmic traffic Pkr Nucleocytoplasmic trafficking disorder (nctd) Cardiovirus Stress granules. Picornavirus Nucleoli Double-stranded rna Eif2ak2 
UnknownThe leader proteins of Theiler's virus and Boone cardiovirus use a combination of short linear motifs (SLiMs) to target RSK kinases to the nuclear pore complex.
Not available
S-EPMC12548433 | biostudies-literature
ProteomicsPKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs
Eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), better known as PKR plays a key role in the response to viral infections and cellular homeostasis by regulating mRNA translation. Upon binding dsRNA, PKR is activated through homodimerization and subsequent autophosphorylation on T...
ORGANISM(S): Homo sapiens (Human) 
2021-05-10 | PXD022564 | Pride
Dsrna binding Viral infection Pkr Autophosphorylation Regulation 
TranscriptomicsInventory of genes expressed in human control hippocampus
Serial analysis of gene expression (SAGE) was used to get a global view of the gene profile in human hippocampus. A library were generated from control hippocampus, obtained by rapid autopsy. Keywords: hippocampus human inventory genes Control hippocampus (used to construct the SAGE control library)...
ORGANISM(S): Homo sapiens 
2005-12-29 | E-GEOD-3928 | biostudies-arrayexpress
UnknownA case of convergent evolution: Several viral and bacterial pathogens hijack RSK kinases through a common linear motif.
Not available
S-EPMC8812568 | biostudies-literature
UnknownThe leader protein of cardioviruses inhibits stress granule assembly.
Not available
S-EPMC3165746 | biostudies-literature
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