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TranscriptomicsA potential role for snoRNA in PKR activation during metabolic stress
PKR (Protein Kinase RNA-activated) is activated by metabolic stress, such as that associated with obesity, and this activation depends on its RNA-binding domain. Here we investigated whether endogenous RNA triggers PKR activation in response to lipid exposure. Our results indicate that snoRNAs (smal...
ORGANISM(S): Mus musculus 
2015-05-08 | E-GEOD-66540 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse NIH3T3 cells over-expressing RNA-dependent serine/threonine protein kinase (PKR)PKR
Global analysis of gene expression in NIH3T3 cells over-expressing RNA-dependent serine/threonine protein kinase (PKR).
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-682 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human NIH 3T3 inducible cell line to study the role of PKR in regulating gene expression
PKR is an interferon induced serine/threonine protein kinase, that is activated by double stranded RNA. PKR plays an important role in the antiviral defense by interferon. In addition to its role in translation, PKR participates in several signaling pathways to transcription. The goal of this experi...
ORGANISM(S): Mus musculus 
2004-01-30 | E-MEXP-50 | biostudies-arrayexpress
ProteomicsPKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs
Eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), better known as PKR plays a key role in the response to viral infections and cellular homeostasis by regulating mRNA translation. Upon binding dsRNA, PKR is activated through homodimerization and subsequent autophosphorylation on T...
ORGANISM(S): Homo sapiens (Human) 
2021-05-10 | PXD022564 | Pride
Dsrna binding Viral infection Pkr Autophosphorylation Regulation 
ProteomicsCardiovirus-Mediated PKR Inhibition Results from Nucleocytoplasmic Trafficking Disruption
Protein kinase R (PKR) is a key antiviral kinase activated by binding double-stranded RNA (dsRNA) produced during viral replication. Upon activation, PKR phosphorylates eIF2α, leading to the inhibition of translation and viral replication. However, many viruses have evolved mechanisms to counteract ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD066206 | Pride
Nucleocytoplasmic traffic Pkr Nucleocytoplasmic trafficking disorder (nctd) Cardiovirus Stress granules. Picornavirus Nucleoli Double-stranded rna Eif2ak2 
ProteomicsHuman DICER helicase domain recruits PKR and dsRNA binding proteins during viral infection
The innate immune response against viruses mainly involves type I interferon (IFN) in mammalian cells. The exact contribution of the RNA silencing machinery remains to be established, but several recent studies indicate that the type III ribonuclease DICER can generate viral siRNAs in specific condi...
ORGANISM(S): Homo sapiens (Human) 
2021-04-15 | PXD019093 | Pride
Virus Dicer Alphavirus Helicase Interferon Pkr Rnai 
ProteomicsSuppression of the nucleic acid precursor ribose 5-phosphate by RNA-mediated antiviral immunity.
We identify that the antiviral protein kinase PKR alters glycolysis. This response is found to be independent of the kinase’s established control of gene expression that is executed through phosphorylation of the Eukaryotic Translation Initiation Factor 2. Instead, a novel substrate is recognised wi...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD036779 | Pride
Metabolism Protein kinase r pkr Ribose 5-phosphate isomerase Antiviral immunity 
TranscriptomicsExpressed dsRNA provokes selective sequence-independent PKR response in transient co-transfection experiments
In mammals, double-stranded RNA (dsRNA) plays roles in sequence-specific RNA interference, sequence-independent interferon response, and RNA editing by adenosine deaminases. We have previously shown that long hairpin dsRNA expression in cultured cells does not activate the interferon response, it is...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-46959 | biostudies-arrayexpress
GenomicsPACT-mediated regulation of endogenous dsRNA sensing by PKR
PACT-mediated regulation of endogenous dsRNA sensing by PKR
PRJNA1123226 | ENA
GenomicsTherapeutic circRNA aptamer alleviates PKR-associated osteoarthritis
Therapeutic circRNA aptamer alleviates PKR-associated osteoarthritis
PRJNA1212714 | ENA
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