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ProteomicsMeant_RSK_BioID_2019
This dataset consists of 33 raw MS files and associated peak lists and result files, acquired on an Orbitrap Fusion Tribrid mass spectrometer operated in Data Dependent Acquisition mode. The files are associated with a manuscript submitted for publication by Antoine Meant et al. titled: RSK promote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-02-07 | MSV000083414 | MassIVE
ProteomicsCardioviruses’ leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic
Proteins from unrelated pathogens, including some RNA or DNA viruses and bacteria can recruit and activate cellular p90-ribosomal protein S6 kinases (RSKs) through a common linear motif. Data suggested a model where pathogens' proteins act to dock the recruited RSKs toward specific substrates, which...
ORGANISM(S): Homo sapiens (Human) 
2022-12-08 | PXD034604 | Pride
P90 ribosomal s6 kinases Picornavirus Nucleocytoplasmic traffic Rsk Cardiovirus Phosphorylation Yopm Nucleoporins Linear motifs 
ProteomicsValidation of known and novel AKT, S6K and RSK targets by targeted MS
Using the global SILAC and label-free phosphoproteomics experiments as a basis, an inclusion list for validation of known and novel AKT, RSK and S6K targets comprising the RxRxxp[ST] motif was generated. Samples were analyzed by PRM-MS.
ORGANISM(S): Mus Musculus 
2023-02-27 | PXD035962 | panorama
ProteomicsLabel-free global phosphoproteomics experiment using PI3K-AKT-mTOR-S6K and RAF-MEK-ERK-RSK pathway activation and inhibition
The signaling network of skeletal muscle cells is controlled by a variety of protein kinases. Although many kinases are known players, their downstream targets are still largely unexplored. To gain further knowledge about the PI3K-AKT-mTOR-S6K and the RAF-MEK-ERK-RSK signaling networks in myotubes, ...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-22 | PXD029678 | Pride
Phosphoproteomics Mouse Akt Rsk Ms S6k Skeletal muscle 
ProteomicsValidation of known and novel AKT, S6K and RSK targets by targeted MS
Based on the global SILAC and label-free phosphoproteomics experiments, we generated an inclusion list for validation of known and novel AKT, RSK and S6K targets containing the RxRxxp[ST] motif. Samples were analyzed by targeted MS using PRM.
ORGANISM(S): Mus musculus (Mouse) 
2023-02-22 | PXD029633 | Pride
Phosphoproteomics Mouse Akt Rsk Targeted ms S6k Skeletal muscle 
ProteomicsQuantitative phosphoproteome of contracting C2 myotubes with pharmacological intervention of the PI3K-AKT-mTOR-S6K and RAF-MEK-ERK-RSK cascades
Various protein kinases are regulating the intracellular signaling network of skeletal muscle cells. Despite that many of the involved kinases are known, their downstream targets have remained largely unexplored. To deepen our understanding of the PI3K-AKT-mTOR-S6K and the RAF-MEK-ERK-RSK signaling ...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-22 | PXD018667 | Pride
Phosphoproteomics Mouse Akt Rsk S6k Skeletal muscle Lc-ms/ms 
ProteomicsIdentification of RSK substrates using an analog-sensitive kinase approach
RSK1 and RSK4 are two of the four members of the p90 ribosomal protein S6 kinases (RSK) family. These kinases are downstream kinases of mitogen-activated protein kinase 1 (ERK or MAPK1) in the ERK MAP kinase pathway. RSKs are implicated in fine tuning of cellular processes such as translation, trans...
ORGANISM(S): Homo sapiens (Human) 
2024-02-06 | PXD047020 | Pride
Rsk1 Rsk4 Mapk pathway Kinase Substrate 
ProteomicsRSK Inhibition Rewires Kinase Networks in Esophageal Cancer
Our study reveals that RSK inhibition reprograms kinase networks to enforce stress adaptation, maintaining oncogenic homeostasis despite perturbations. These findings highlight a potential therapeutic window for early intervention strategies, suggesting that combination strategies may enhance the ef...
ORGANISM(S): Homo Sapiens 
2025-06-02 | PXD064548 |
ProteomicsRSK Inhibition Rewires Kinase Networks in Esophageal Cancer (proteomics)
Our study reveals that RSK inhibition reprograms kinase networks to enforce stress adaptation, maintaining oncogenic homeostasis despite perturbations. These findings highlight a potential therapeutic window for early intervention strategies, suggesting that combination strategies may enhance the ef...
ORGANISM(S): Homo Sapiens 
2025-06-03 | PXD064585 |
GenomicsMitochondrial signatures shape phenotype switching and apoptosis in response to PLK1 and RSK inhibitiors in melanoma
Mitochondrial signatures shape phenotype switching and apoptosis in response to PLK1 and RSK inhibitiors in melanoma
PRJNA1103800 | ENA
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