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ProteomicsValidation of known and novel AKT, S6K and RSK targets by targeted MS
Using the global SILAC and label-free phosphoproteomics experiments as a basis, an inclusion list for validation of known and novel AKT, RSK and S6K targets comprising the RxRxxp[ST] motif was generated. Samples were analyzed by PRM-MS.
ORGANISM(S): Mus Musculus 
2023-02-27 | PXD035962 | panorama
ProteomicsLabel-free global phosphoproteomics experiment using PI3K-AKT-mTOR-S6K and RAF-MEK-ERK-RSK pathway activation and inhibition
The signaling network of skeletal muscle cells is controlled by a variety of protein kinases. Although many kinases are known players, their downstream targets are still largely unexplored. To gain further knowledge about the PI3K-AKT-mTOR-S6K and the RAF-MEK-ERK-RSK signaling networks in myotubes, ...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-22 | PXD029678 | Pride
Phosphoproteomics Mouse Akt Rsk Ms S6k Skeletal muscle 
ProteomicsValidation of known and novel AKT, S6K and RSK targets by targeted MS
Based on the global SILAC and label-free phosphoproteomics experiments, we generated an inclusion list for validation of known and novel AKT, RSK and S6K targets containing the RxRxxp[ST] motif. Samples were analyzed by targeted MS using PRM.
ORGANISM(S): Mus musculus (Mouse) 
2023-02-22 | PXD029633 | Pride
Phosphoproteomics Mouse Akt Rsk Targeted ms S6k Skeletal muscle 
ProteomicsInhibition of S6K lowers age-related inflammation and immunosenescence and increases lifespan via the endolysosomal system
The nutrient-sensing Target of Rapamycin complex 1 (TORC1) is an evolutionarily conserved regulator of longevity. S6 kinase (S6K) is an essential downstream mediator for the effect of TORC1 on longevity. However, mechanistic insights on how TORC1-S6K signalling promotes lifespan and healthspan are s...
ORGANISM(S): Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2024-01-12 | PXD035293 | Pride
Inhibition of s6k lowers age-related inflammation and immunosenescence and increases lifespan via the endolysosomal system 
ProteomicsQuantitative phosphoproteome of contracting C2 myotubes with pharmacological intervention of the PI3K-AKT-mTOR-S6K and RAF-MEK-ERK-RSK cascades
Various protein kinases are regulating the intracellular signaling network of skeletal muscle cells. Despite that many of the involved kinases are known, their downstream targets have remained largely unexplored. To deepen our understanding of the PI3K-AKT-mTOR-S6K and the RAF-MEK-ERK-RSK signaling ...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-22 | PXD018667 | Pride
Phosphoproteomics Mouse Akt Rsk S6k Skeletal muscle Lc-ms/ms 
GenomicsThe ROS/AKT/S6K axis induces corneal epithelial dysfunctions under LED blue light exposure
The ROS/AKT/S6K axis induces corneal epithelial dysfunctions under LED blue light exposure
PRJNA1188472 | ENA
TranscriptomicsThe ROS/AKT/S6K axis induces corneal epithelial dysfunctions under LED blue light exposure
In recent years, concerns have escalated regarding eye health problems arising from Light-emitting diode (LED), which emits high-energy blue light (BL), potentially causing corneal epithelial dysfunctions (CEpD). Nevertheless, the mechanisms underlying this damage remain poorly comprehended. This st...
ORGANISM(S): Homo sapiens 
2025-12-01 | GSE282378 | GEO
UnknownTargeting S6K/NFκB/SQSTM1/Polθ signaling to suppress radiation resistance in prostate cancer.
Not available
S-EPMC12175492 | biostudies-literature
UnknownC. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension.
Not available
S-EPMC4823261 | biostudies-literature
UnknownInhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system.
Not available
S-EPMC11031405 | biostudies-literature
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