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ProteomicsRAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA
Alternative lengthening of telomeres (ALT) is a homology-directed repair (HDR) mechanism of telomere elongation that controls proliferation in subsets of highly aggressive cancer. Recent studies have revealed that TERRA (telomere repeat-containing RNA) acts to initiate ALT-associated HDR (ALT-HDR). ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD035943 | Pride
Cancer Alt Terra Homology-directed repair Chromatin Transcription Telomere Rad51ap1 
UnknownSF3B1 mutation and ATM deletion codrive leukemogenesis via centromeric R-loop dysregulation.
Not available
S-EPMC10471171 | biostudies-literature
UnknownThe nociceptive innervation of the normal and osteoarthritic mouse knee.
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S-EPMC7020657 | biostudies-literature
UnknownWilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model.
Not available
S-EPMC5221658 | biostudies-literature
MetabolomicsER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis
The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...
2017-06-23 | MTBLS472 | MetaboLights
UnknownA sensitive and specific non-invasive urine biomarker panel for prostate cancer detection.
Not available
S-EPMC12789725 | biostudies-literature
UnknownOccult metastases in lymph nodes predict survival in resectable non-small-cell lung cancer: report of the ACOSOG Z0040 trial.
Not available
S-EPMC3221530 | biostudies-literature
UnknownEpithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660).
Not available
S-EPMC5698569 | biostudies-literature
UnknownA multi-center screening trial of rasagiline in patients with amyotrophic lateral sclerosis: Possible mitochondrial biomarker target engagement.
Not available
S-EPMC4610861 | biostudies-literature
UnknownDesigning a virtual mental health consultation program to support and strengthen childcare centers impacted by COVID-19: A randomized controlled trial protocol.
Not available
S-EPMC9694403 | biostudies-literature
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