Sort   by:  
 Page size 
ProteomicsNardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of apoptotic pathways. Here, we find that development of anoikis resistance and metastasis of KrasG12D-driven PDAC in mice is accelerated by deleting Plk3, ex...
ORGANISM(S): Homo sapiens (Human) 
2023-12-23 | PXD042993 | Pride
Plk3 Nardilysin (nrdc) metalloendopeptidase cleavage C-fos Anoikis Pancreatic ductal adenocarcinoma (pdac) Post-translational mechanism (ptm) Genetically engineered mouse models (gemms) Plk1 Kinase activation Metastasis 
UnknownEffect of bridgmanite-ferropericlase grain size evolution on Earth's average mantle viscosity: implications for mantle convection in early and present-day Earth.
Not available
S-EPMC11615032 | biostudies-literature
ProteomicsSARS-CoV2 manipulates multiple NK ligands and inhibits NK activation, but this can be overcome by ADNKA, which is strongly activated by non-Spike targeting antibodies
SARS-CoV2 is recognised the antagonise the interferon response, and functioning interferon responses are critical in determining the severity of disease. However, whether the virus antagonises cellular immunity has not been determined. We used quantitative plasma membrane proteomics in lung epitheli...
ORGANISM(S): Homo sapiens (Human) 
2022-05-26 | PXD025000 | Pride
Sars-cov2 Nk ligands Adnka 
UnknownA Mutation in the Mitochondrial Aspartate/Glutamate Carrier Leads to a More Oxidizing Intramitochondrial Environment and an Inflammatory Myopathy in Dutch Shepherd Dogs.
Not available
S-EPMC6918910 | biostudies-literature
UnknownCharacterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.
Not available
S-EPMC3406710 | biostudies-literature
UnknownMolecular epidemiology of coagulase-negative Staphylococcus species isolated at different lactation stages from dairy cattle in the United States.
Not available
S-EPMC6507897 | biostudies-literature
UnknownSRT1720 improves survival and healthspan of obese mice.
Not available
S-EPMC3216557 | biostudies-literature
UnknownDiscovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Not available
S-EPMC7610439 | biostudies-literature
UnknownIdentification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis.
Not available
S-EPMC5828602 | biostudies-literature
GenomicsWhole Genome Sequencing of a Triple Negative Breast Cancer Patient: Matched Primary Tumor, Normal, Metastasis and Xenograft samples

Breast Cancer Subject Participant ID 700064 (Source Sample names: 6888 and 206). We used massively parallel DNA sequencing technologies to screen entire genomes, in an unbiased manner, for genetic changes associated with tumor growth and metastasis. We describe the complete genome sequence ...

phs000245.v1.p1 | EGA
Sort   by:  
 Page size