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TranscriptomicsGenomic analyses reveal miR-137 broad impact on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells
miR-137 plays critical roles in the nervous system and tumor development. An increase in its expression is required for neuronal differentiation while its reduction is implicated in gliomagenesis. To evaluate the potential of miR-137 in glioblastoma therapy, we conducted genome-wide target mapping i...
ORGANISM(S): Homo sapiens 
2014-02-11 | E-GEOD-53220 | biostudies-arrayexpress
ProteomicsTMT-based quantitative analysis of brain whole proteome of miR-137 mouse models
Recent genetic evidence has revealed microRNA-137 (miR-137) as a risk gene in schizophrenia and autism spectrum disorder (ASD), and the following cellular studies have demonstrated the importance of miR-137 in regulating neurogenesis. We have generated miR-137 knockout mice which display behaviors t...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-17 | PXD003874 | Pride
Proteomics Tmt Autism spectrum disorder Mass spectrometry Schizophrenia Mir-137 
TranscriptomicsTranscriptional consequences of manipulating the candidate schizophrenia susceptibility gene miR-137 in human neural progenitor cells
In the largest published genome-wide association study (GWAS) of schizophrenia to date (PGC1), the most significant association (P = 1.6 X 10-11) was observed at an intronic variant (rs1625579) within the MIR137 host gene (MIR137HG). In this study we have performed genome-wide RNA profiling of a hum...
ORGANISM(S): Homo sapiens 
2014-02-10 | E-GEOD-49793 | biostudies-arrayexpress
TranscriptomicsGene expression signatures in a human bladder cancer cell line SW780 transfected with miR-137 precursor molecule
To clarify the effect of miRNAs, we carried out a gene expression microarray analysis of SW780 cells transfected with a miR-137 precursor or a negative control. We found that 1,326 probe sets (1,016 unique genes) were downregulated (>2-fold) by ectopic miR-137 expression, including the previously r...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-41760 | biostudies-arrayexpress
GenomicsAnalyzing gene expression profiles in the brain of miR-137 knockout mice versus wild-type mice
Analyzing gene expression profiles in the brain of miR-137 knockout mice versus wild-type mice
PRJNA1045574 | ENA
GenomicsAnalyzing gene expression profiles in the liver of miR-137 knockout mice versus wild-type mice
Analyzing gene expression profiles in the liver of miR-137 knockout mice versus wild-type mice
PRJNA1043138 | ENA
GenomicsMiR-137 gain of function in the dorsomedial striatum promotes continued cocaine-taking despite punishment in rats
MiR-137 gain of function in the dorsomedial striatum promotes continued cocaine-taking despite punishment in rats
PRJNA1032568 | ENA
UnknownmiR-137: a new player in schizophrenia.
Not available
S-EPMC3958910 | biostudies-literature
UnknownMiR-137 Deficiency Causes Anxiety-Like Behaviors in Mice.
Not available
S-EPMC6831983 | biostudies-literature
TranscriptomicsGenomic analyses reveal miR-137 broad impact on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells
miR-137 plays critical roles in the nervous system and tumor development. An increase in its expression is required for neuronal differentiation while its reduction is implicated in gliomagenesis. To evaluate the potential of miR-137 in glioblastoma therapy, we conducted genome-wide target mapping i...
ORGANISM(S): Homo sapiens 
2014-02-11 | GSE53220 | GEO
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