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ProteomicsMulti-omics profiling of non-small cell lung cancer patient-derived xenografts reveals proteome and phosphoproteome remodeling associated with patient outcome
131 patient-derived xenograft models were generated for non-small cell lung carcinoma and were profiled by analysis of gene copy number variation, whole exome sequence, methylome, transcriptome, proteome, and phospho(Tyr)-proteome. Proteome profiling resolved the known major histology subtypes and r...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-11-24 | PXD016579 | Pride
Nsclc Tmt Lung Pdx 
ProteomicsMitochondrial aconitase (ACO2) modulates iron homeostasis and is associated with outcomes in poor prognosis aggressive non-small cell lung cancer
NSCLC accounts for 85% of lung cancers, the most frequently diagnosed and leading cause of cancer related death. An ACO2-iron acis regulates intracellular iron and consequently the particularly aggressive phenotype associated with NSCLC engraftment and poor prognosis. These findings suggest that NSC...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-09-19 | PXD028556 | Pride
Aggressiveness Engraftment Nsclc Aco2 Iron 
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