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GenomicsPathophysiological insights into ACO2-related inherited disorders through combined functional and multi-omic analyses of ACO2 patient-derived fibroblasts
Pathophysiological insights into ACO2-related inherited disorders through combined functional and multi-omic analyses of ACO2 patient-derived fibroblasts
PRJNA1469605 | ENA
ProteomicsMitochondrial aconitase (ACO2) modulates iron homeostasis and is associated with outcomes in poor prognosis aggressive non-small cell lung cancer
NSCLC accounts for 85% of lung cancers, the most frequently diagnosed and leading cause of cancer related death. An ACO2-iron acis regulates intracellular iron and consequently the particularly aggressive phenotype associated with NSCLC engraftment and poor prognosis. These findings suggest that NSC...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-09-19 | PXD028556 | Pride
Aggressiveness Engraftment Nsclc Aco2 Iron 
TranscriptomicsPathophysiological insights into ACO2-related inherited disorders through combined functional and multi-omic analyses of ACO2 patient-derived fibroblasts
ACO2 encodes the mitochondrial aconitase, involved in the second step of the tricarboxylic acid cycle. ACO2 variants cause isolated dominant or recessive optic atrophy, characterized by the degeneration of the optic nerves and leading to vision loss with high clinical heterogeneity, which ranges fro...
ORGANISM(S): Homo sapiens 
2026-07-29 | GSE332997 | GEO
TranscriptomicsOverexpression of Mitochondrial Aconitase in HT29 Colon Cancer Cells Attenuates beta-Catenin Signaling Pathway via Metabolic Changes of NADPH and ROS
Our previous proteomics analysis suggested down-regulation of mitochondrial aconitase (ACO2) plays an important role in colorectal cancer. To evaluate the effect of mitochondrial aconitase overexpression on the metabolic and signaling pathway changes in colon cancer cell line HT29, we generated two ...
ORGANISM(S): Homo sapiens 
2010-01-14 | E-MEXP-1996 | biostudies-arrayexpress
UnknownACO2 clinicobiological dataset with extensive phenotype ontology annotation.
Not available
S-EPMC8342444 | biostudies-literature
UnknownDeacetylation of ACO2 Is Essential for Inhibiting Bombyx mori Nucleopolyhedrovirus Propagation.
Not available
S-EPMC10612070 | biostudies-literature
UnknownMitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non-Small Cell Lung Cancer.
Not available
S-EPMC9808373 | biostudies-literature
UnknownExpanding the clinical and phenotypic heterogeneity associated with biallelic variants in ACO2.
Not available
S-EPMC7318087 | biostudies-literature
UnknownBinding of α-synuclein to ACO2 promotes progressive mitochondrial dysfunction in Parkinson's disease models.
Not available
S-EPMC11533713 | biostudies-literature
UnknownComplex hereditary spastic paraplegia associated with episodic visual loss caused by ACO2 variants.
Not available
S-EPMC7838304 | biostudies-literature
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