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GenomicsEic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly
CENP-A chromatin the foundation for kinetochore assembly in all eukaryotes. CENP-A is incorporated outside of S phase and depends on its chaperone HJURPScm3, and Mis18 in vertebrates and fission yeast. The recruitment of Mis18 and HJURPScm3 to centromeres is cell cycle regulated. Vertebrate Mis18 a...
ORGANISM(S): Schizosaccharomyces pombe 
2014-05-19 | E-GEOD-54685 | biostudies-arrayexpress
GenomicsEic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly
CENP-A chromatin the foundation for kinetochore assembly in all eukaryotes. CENP-A is incorporated outside of S phase and depends on its chaperone HJURPScm3, and Mis18 in vertebrates and fission yeast. The recruitment of Mis18 and HJURPScm3 to centromeres is cell cycle regulated. Vertebrate Mis18 as...
ORGANISM(S): Schizosaccharomyces pombe 
2014-05-19 | GSE54685 | GEO
ProteomicsDirect recruitment of Mis18 to interphase spindle poles promotes CENP-A chromatin assembly.
CENP-A chromatin specifies mammalian centromere identity, and its chaperone HJURP replenishes CENP-A when recruited by the Mis18 complex (Mis18C) via M18BP/KNL2 to CENP-C at kinetochores during interphase. However, the Mis18C recruitment mechanism remains unresolved in species lacking M18BP1, such a...
ORGANISM(S): Schizosaccharomyces pombe 927 
2023-09-18 | PXD045191 | Pride
Mis18 complex Fission yeast Cenp-a chromatin Centromere 
UnknownCentromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization.
Not available
S-EPMC4818781 | biostudies-literature
UnknownMolecular basis for Cdk1-regulated timing of Mis18 complex assembly and CENP-A deposition.
Not available
S-EPMC5452045 | biostudies-literature
UnknownSubunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.
Not available
S-EPMC6677171 | biostudies-literature
UnknownStructural basis for Mis18 complex assembly and its implications for centromere maintenance.
Not available
S-EPMC11315898 | biostudies-literature
ProteomicsPLK1-Mediated Phosphorylation Cascade Activates Mis18 Complex to Ensure Centromere Inheritance
Accurate chromosome segregation requires the attachment of spindle microtubules to centromeres, which are epigenetically defined by the enrichment of CENP-A nucleosomes. During DNA replication, existing CENP-A nucleosomes undergo dilution as they get redistributed among the two DNA strands. To prese...
ORGANISM(S): Homo sapiens (Human) 
2025-02-15 | PXD053197 | Pride
Hjurp Plk1 Mis18 Phosphorylation Cross-linking mass spectrometer 
UnknownDifferential Binding Partners of the Mis18α/β YIPPEE Domains Regulate Mis18 Complex Recruitment to Centromeres.
Not available
S-EPMC4899240 | biostudies-literature
UnknownDirect recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly.
Not available
S-EPMC7618776 | biostudies-literature
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