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ProteomicsDrosophila melanogaster nuclear matrix proteome
Nucleus is a highly structured organelle and contains many functional compartments. While the structural basis for this complex spatial organization of compartments is unknown, a major component of this organization is likely to be the non-chromatin scaffolding called nuclear matrix (NuMat). Exp...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2011-05-05 | PRD000255 | Pride
ProteomicsIdentification of evolutionarily conserved nuclear matrix proteins and their prokaryotic origins
Compared to prokaryotic cells, a typical eukaryotic cell is much more complex along with its endomembrane system and membrane-bound organelles. Although the endosymbiosis theories convincingly explain the evolution of membrane-bound organelles such as mitochondria and chloroplasts, very little is un...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Drosophila melanogaster (Fruit fly) 
2021-01-26 | PXD012926 | Pride
Core nuclear matrix proteome Nuclear evolution Nuclear matrix Nucleoskeleton Nuclear architecture 
ProteomicsComparison of Nuclear Matrix and Mitotic Chromosome Scaffold proteins in Drosophila S2 cells – Transmission of hallmarks of nuclear organization through mitosis
During open mitosis chromatin condenses to form chromosomes and decondenses post-mitotically to re-occupy their designated nuclear territory in a precisely lineage specific manner. This necessitates that features of nuclear architecture persist through mitosis. Here we present a proteomic study, whi...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-07-17 | PXD008404 | Pride
Nuclear matrix Drosophila melanogastor S2 cells Nuclear architecture Mitotic chromosome scaffold Mitosis 
ProteomicsFixed and unalterable Matrix Associated Regions in Drosophila melanogaster genome
Eukaryotic genome is compartmentalized into structural and functional domains. One of the concepts of higher order organization of chromatin posits that the DNA is organized in constrained loops that behave as independent functional domains. A predominantly ribo-proteinaceous nucleoskeleton, termed ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-10-25 | PXD031279 | Pride
Mars Numat Development Drosophila Nuclear matrix 
TranscriptomicsTranscriptional profiling of PRDM2 Knock down vs.controlGFPsh proliferating C2C12 Myoblasts
Knockdown of PRDM2 led to precocious differentiation. To understand the molecular basis for this phenotype, we performed microaary analysis of growing myoblasts. Genes differentially regulated by PRDM2 knock down were reveraled by microarray analysis using NIA15K mouse chips. Control and knock down...
ORGANISM(S): Mus musculus 
2015-06-30 | E-GEOD-58675 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of PRDM2 Knock down vs.controlGFPsh Quiescent C2C12 Myoblasts (G0 enriched)
Knockdown of PRDM2 led to precocious differentiation. To understand the molecular basis for this phenotype, we performed microaary analysis of quiescent myoblasts. Genes differentially regulated by PRDM2 knock down were reveraled by microarray analysis using affymetrix mouse chips. Control and knoc...
ORGANISM(S): Mus musculus 
2015-06-30 | E-GEOD-58674 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of PRDM2 Knock down vs.controlGFPsh differentiated C2C12 Myoblasts (D28hrs)
Knockdown of PRDM2 led to precocious differentiation. To understand the molecular basis for this phenotype, we performed microaary analysis of 28hr differentiated myoblasts. Genes differentially regulated by PRDM2 knock down were reveraled by microarray analysis using affymetrix mouse chips. Contro...
ORGANISM(S): Mus musculus 
2015-06-30 | E-GEOD-58673 | biostudies-arrayexpress
TranscriptomicsVertebrate GAGA factor associated insulator elements demarcate homeotic genes in the HOX clusters
Hox genes impart segment identity to body structures along the anterior-posterior axis and are crucial for the proper development of all organisms. Multiple regulatory elements, best defined in Drosophila melanogaster, ensure that Hox expression patterns follow the spatial and temporal colinearity r...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-42941 | biostudies-arrayexpress
UnknownGenomics of rare genetic diseases-experiences from India.
Not available
S-EPMC6760067 | biostudies-literature
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