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Cancers have been associated with a diverse array of genomic alterations. To understand such alterations in breast invasive carcinoma at the level of cellular mechanisms, we have applied affinity-purification mass spectrometry to delineate comprehensive biophysical interaction networks for 40 freque...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD025931 | Pride
Cancers have been associated with diverse sets of genomic alterations, many of which are rare with uncertain significance. To understand the cellular mechanisms impacted by such alterations in breast invasive carcinoma, we have applied affinity-purification mass spectrometry to delineate comprehensi...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD019639 | Pride
Type I Protein Arginine Methyltransferases (PRMTs) catalyze asymmetric dimethylation of arginine residues on numerous proteins. Type I PRMTs and their substrates have been implicated in human cancers, suggesting that inhibiting Type I PRMT activity offers a tractable approach for therapeutic interve...
ORGANISM(S): Homo sapiens (Human) 
2019-09-10 | PXD012747 | Pride
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