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MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsFunctional Comparison of Chronological and In Vitro Aging: Differential Role of the Cytoskeleton and Mitochondria in Mesenchymal Stromal Cells
Mesenchymal stromal cells (MSCs) are of high relevance for the regeneration of mesenchymal tissues such as bone and cartilage. The promising role of MSCs in cell-based therapies and tissue engineering appears to be limited due to a decline of their regenerative potential with increasing donor age, t...
ORGANISM(S): Rattus norvegicus 
2013-01-05 | E-GEOD-36596 | biostudies-arrayexpress
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
TranscriptomicsEffects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Calorie restriction (CR) is the most robust non-genetic intervention to universally delay the onset of age-related diseases and extend mean and maximum lifespan. However, species, strain, sex, diet, age of onset, and level of CR are emerging as important variables to consider for a successful CR res...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-81959 | biostudies-arrayexpress
ProteomicsAging Mouse Brain Mitochondria LC-MS/MS
This study investigates the proteomic alterations in brain mitochondria isolated from 5- (mature), 12- (old), and 24-month-old (aged) mice to examine normal "healthy" aging. Using quantitative mass-spectrometry based super-SILAC, our findings revealed global proteomic changes in brain mitochondria i...
ORGANISM(S): Mus musculus (Mouse) 
2015-01-27 | PXD001370 | Pride
Mitochondria Mouse Ttof 5600 
TranscriptomicsHuman iPSC-based Modeling of Late-Onset Disease using Progerin-induced Aging
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) sets their identity back to an embryonic age. This presents a fundamental hurdle for modeling late-onset disorders using iPSC-derived cells. We therefore developed a strategy to induce age-like features in multiple iPSC-derived li...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-52431 | biostudies-arrayexpress
TranscriptomicsTissue-specific dysregulation of DNA methylation in aging
The normal aging process is a complex phenomenon associated with physiological alterations in the function of cells and organs over time. Although an attractive candidate for mediating transcriptional dysregulation, the contribution of epigenetic dysregulation to these progressive changes in cellul...
ORGANISM(S): Rattus norvegicus 
2010-05-01 | E-GEOD-17332 | biostudies-arrayexpress
TranscriptomicsMitofusin 2 expression in muscle decreases during aging and generates a gene signature characteristic of aged muscle
Mitochondrial fusion and fission proteins regulate mitochondrial quality control and mitochondrial metabolism. In turn, mitochondrial dysfunction is associated with aging, although its causes are still under debate. Here, we show that aging is characterized by a progressive reduction of Mitofusin 2 ...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-71501 | biostudies-arrayexpress
ProteomicsComplexome profiling of mitochondria to study organismic consequences of aging in Podospora anserina
Podospora anserina is an established aging model with a strong mitochondrial etiology of aging. Here we performed a complexome analysis of isolated mitochondria to study age-related changes of assembled mitochondrial protein complexes. The analysis revealed prominent age-related alterations in oxida...
ORGANISM(S): Podospora anserina 
2022-02-22 | PXD029352 | Pride
Lc-msms Podospora anserina Oxidative phosphorylation system Mitochondria Aging Complexome profiling 
GenomicsMitochondria-lysosome coupling contributes to lysosome acidification and aging
Mitochondria-lysosome coupling contributes to lysosome acidification and aging
PRJNA1240233 | ENA
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