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MetabolomicsCross-Species Mitochondrial Rescue by Gastrodia elata-Derived Extracellular Vesicles Protects the Stressed Mammalian Heart
In this study, we developed Gastrodia elata (G. elata)-derived extracellular vesicles (GE-EVs) to achieve functional rescue of the stressed mammalian heart. Using RBM24 phosphorylation-deficient (S181A, A/A) mice, we demonstrated that GE-EVs have a profound cross-species rescue effect on mitochondri...
2026-04-09 | MTBLS14245 | MetaboLights
MetabolomicsCross-Species Mitochondrial Rescue by Gastrodia elata-Derived Extracellular Vesicles Protects the Stressed Mammalian Heart
In this study, we developed Gastrodia elata (G. elata)-derived extracellular vesicles (GE-EVs) to achieve functional rescue of the stressed mammalian heart. Using RBM24 phosphorylation-deficient (S181A, A/A) mice, we demonstrated that GE-EVs have a profound cross-species rescue effect on mitochondri...
2026-04-09 | MTBLS14243 | MetaboLights
MetabolomicsProteomic and metabolomic profiling of extracellular vesicles produced by human gut archaea

Gastrointestinal bacteria interact with the host and each other through various mechanisms, including the production of extracellular vesicles (EVs). However, the composition and potential roles of EVs released by gut archaea are poorly understood. Here, we study EVs produced by four strains of h...

2025-07-01 | MTBLS12422 | MetaboLights
MetabolomicsParallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia (Lipidomic analysis on extracellular vesicles)

Acute myeloid leukemia (AML) is an aggressive disease with a high relapse rate. In this study, we map the metabolic profile of CD34+(CD38low/-) AML cells and the extracellular vesicle signatures in circulation from AML patients at diagnosis. CD34+ AML cells display high antioxidant glutathione le...

2024-12-04 | MTBLS11523 | MetaboLights
ProteomicsProteomics Characterization of Mitochondrial-Derived Vesicles Under Oxidative Stress
Mitochondria share attributes of vesicular transport with their bacterial ancestors given their ability to form mitochondrial-derived vesicles (MDVs). MDV formation enhances with stress and has been explored for its potential role in mitochondrial-directed cellular and extracellular signalling. Alth...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-08 | PXD020110 | Pride
Mdv Lc-msms Mitochondria Rat Heart Cardiac mitochondria Mitochondrial-derived vesicles Oxidative stress 
ProteomicsYeast Mitochondrial Derived Vesicles (MDVs) have membrane potential and contain a functional ATP synthase
Mitochondria are responsible for the production of energy and for essential metabolic pathways in the cell, as well as fundamental processes such as apoptosis and aging. Interestingly, while the import machinery of proteins into mitochondria is thoroughly understood, there is currently no known prot...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-01-29 | PXD035192 | Pride
Mitochondrial derived vesicles Atp synthase 
MetabolomicsVesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancer

Selective autophagy of mitochondria is known to promote survival and progression of cancer cells in various malignancies, including triple-negative breast cancer (TNBC). Here, we investigate the essential metabolic adaptations that support mitochondrial quality control in cancer cells with the ai...

2025-09-30 | MTBLS13037 | MetaboLights
ProteomicsYeast Mitochondrial Derived Vesicles (MDVs) have membrane potential and contain a functional ATP synthase-Part 2
Mitochondria are responsible for the production of energy and for essential metabolic pathways in the cell, as well as fundamental processes such as apoptosis and aging. Interestingly, while the import machinery of proteins into mitochondria is thoroughly understood, there is currently no known prot...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-01-29 | PXD039191 | Pride
Vesicles Atp synthase Yeast mitochondria 
ProteomicsBrain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
Supporting TMT MS data for paper (doi: 10.1016/j.neuron.2021.12.029) by Goldsmith J. et al., titled "Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons". Index of RAW files uploaded: AO3068-3079: Fractionated (12 fr...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-08-01 | MSV000092565 | MassIVE
Proteomics3T3-L1A-derived Extracellular Vesicles Impact the Proteomic Profile of Breast Cancer Cells
In this study, we employed proteomic analysis to gain deeper insights into the role of EVs in breast adiponcosis, providing novel evidence on the role of adipocyte-derived EVs in sustaining mitochondrial metabolism in breast cancer cells.
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD059789 | Pride
Breast cancer Dia Mitochondrial metabolism Orbitrap Fasp Extracellular vescicles 
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