Sort   by:  
 Page size 
ProteomicsMitotic bookmarking redundancy by nuclear receptors mediates robust post-mitotic reactivation of the pluripotency network.
Mitotic bookmarking transcription factors (TFs) are thought to mediate rapid and accurate post-mitotic gene reactivation. However, the loss of individual bookmarking TFs often leads to the deregulation of only a small proportion of their mitotic targets, raising doubts on the significance and import...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-20 | PXD038950 | Pride
Nuclear receptors Pluripotency Esrrb Nr5a2 Es cells Mitotic bookmarking 
TranscriptomicsMitotic Transcriptional Clearance of Actively Engaged Pol II Through Transcriptional Elongation Control
Chromatin is highly condensed and transcriptionally repressed during mitosis. Although it is established that some general transcription factors are inactivated by phosphorylation at mitosis, many details of mitotic transcriptional repression and its underlying mechanisms are largely unknown. Here, ...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-71848 | biostudies-arrayexpress
GenomicsFoxA1 binding in asynchronous and mitotic HUH7 cells
During mitosis, RNA polymerase and most transcription factors are excluded from the chromosomes and transcription ceases. The transcriptional re-activation of the genome, following mitosis, requires the re-setting of cell-type specific programs that were initially established during development. H...
ORGANISM(S): Homo sapiens 
2013-03-31 | E-GEOD-39241 | biostudies-arrayexpress
TranscriptomicsDMRT6 coordinates the transition between mitotic and meiotic developmental programs during mamalian spermatogenesis
In mammals, a key transition in spermatogenesis is the exit from spermatogonial differentiation and mitotic proliferation and the entry into spermatocyte differentiation and meiosis. Although several genes that regulate this transition have been identified, how it is controlled and coordinated remai...
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-60440 | biostudies-arrayexpress
GenomicsSpecific mitotic chromatin association of the major notch effector RBPJ and its implication for transcriptional memory
From the cell-based investigation, RBPJ is one of the few proteins retained on chromatin during cell division. ChIP-seq experiments were performed to understand the binding pattern of RBPJ between interphase and mitosis and to identify the genes requiring RBPJ binding for the maintenance of transcri...
ORGANISM(S): Mus musculus 
2014-05-14 | E-GEOD-45889 | biostudies-arrayexpress
ProteomicsCAMK2D recruits RNF8-MAD2 complex to RNA splicing proteins for mitotic checkpoint activation in GBM
Glioblastoma (GBM) is a lethal brain tumor with remarkable intra-tumoral heterogeneity and therapeutic resistance which is linked to glioma stem cell (GSC). GSC contains unstable genome and elevated genomic instability could impair GSC self-renewal and tumorigenicity. In addition, GSC displays great...
ORGANISM(S): Homo Sapiens (human) 
2023-07-21 | PXD038123 | JPOST Repository
GenomicsHeat shock transcription factors demonstrate a distinct mode of interaction with mitotic chromosomes
Heat shock transcription factors demonstrate a distinct mode of interaction with mitotic chromosomes
PRJNA884392 | ENA
ProteomicsFAIRE-MS reveals mitotic retention of transcriptional regulators on a proteome-wide scale
FAIRE-MS reveals mitotic retention of transcriptional regulators on a proteome-wide scale
ORGANISM(S): Homo Sapiens 
PXD033135 |
GenomicsA new transcription factor for mitosis: In S. pombe, the RFX transcription factor Sak1 works with forkhead factors to regulate mitotic expression (ChIP-Seq)
Many genes are transcriptionally regulated as a function of the cell cycle; genes needed for mitosis are strongly cell cycle regulated. From yeasts to humans, forkhead transcription factors are involved in mitotic gene expression. However, the mechanisms of regulation are unclear, especially since f...
ORGANISM(S): Schizosaccharomyces pombe 
2014-08-25 | E-GEOD-60712 | biostudies-arrayexpress
TranscriptomicsMYC is a major determinant of mitotic cell fate
Purpose: To determine global gene expression changes following siRNA knockdown of Myc, Kcnk1, and Snta1 compared to non-targeting siRNAs or mock-transfected cells Methods: Total RNA was processed using the Illumina TruSeq Stranded mRNA Sample Preparation Kit according to manufacturer’s protocol. Gen...
ORGANISM(S): Homo sapiens 
2015-07-13 | E-GEOD-68219 | biostudies-arrayexpress
Sort   by:  
 Page size