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ProteomicsInterrogating the higher order structures of snake venom proteins
Snake venoms contain complex mixtures of proteins that play vital roles in the survival of venomous snakes. In line with their diverse pharmacological activities, the protein compositions of snake venoms can be highly variable, and efforts to characterise the primary struct...
ORGANISM(S): Vertebrata <Metazoa> 
2020-02-17 | PXD016503 | Pride
Snake venom Lc-ms/ms 
ProteomicsAltered N-linked Glycosylation in Endometrial Cancer
It has been recognised for a long time that cell surface glycans plays a vital role in the biological process and their altered form can lead to cancer. However, the molecular details and regulatory mechanism between the glycans and cancer is yet not clear. Over the past decade mass spectrometry-bas...
ORGANISM(S): Homo sapiens (Human) 
2020-11-27 | PXD019425 | Pride
Biomarker Lymph node metastasis Endometrial cancer Glycan imaging 
ProteomicsSpheroids treated with and without Drug
MALDI MSI for monitoring of drug response in primary cancer spheroids
ORGANISM(S): Homo sapiens (Human) 
2019-09-03 | PXD013069 | Pride
Spheroids 
ProteomicsLabel Free Quantification Mass Spectrometry Identifies Protein Markers of Chemoresistance in Serous Ovarian Cancer
Ovarian cancer is still the most lethal gynecological cancer, despite advances in patients’ strati-fication and treatment. Only about 80% of patients respond to the first line of treatment and many suffer a relapse with a treatment resistant disease. Here, we have identified three potential markers ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD033785 | Pride
Chemoresistance Mass-spectrometry Ovarian cancer 
ProteomicsCancer tissue classification using supervised machine learning applied to MALDI mass spectrometry imaging
With the current clinical available technologies, not all cancers are staged accurately. Because of this a large percentage of patients are misclassified before treatment, leading to under or over treatment. Therefore, a classification system based on the molecular feature is required to deter-mine ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025594 | Pride
Machine learning (ml) Matrix assisted laser desorption/ionization mass spectrometry imaging (maldi msi) Lymph node metastasis (lnm) Endometrial cancer (ec) Colorectal cancer (crc) 
ProteomicsCancer tissue classification using machine learning applied to MALDI MSI and high resolution H&E stained images
Aim is to identify a panel of m/z markers for the early detection of colorectal cancer (CRC). Identification of a molecular pattern that can distinguish the primary tumours of colorectal cancer with lymph node metastasis compared to those without. Materials and Methods: Using MALDI MSI data, we deve...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD019662 | Pride
Crc colorectal cancer machine learning maldi msi matrix assisted laser desorption/ionisation mass spectrometry imaging 
ProteomicsCancer tissue classication using machine learning applied to MALDI MSI and high resolution H&E stained images
To identify a panel of m/z markers for the early detection of colorectal cancer (CRC). Identication of a molecular pattern that can distinguish the primary tumours of colorectal cancer with lymph node metastasis compared to those without. Using MALDI MSI data,we developed and validated a machine lea...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD019653 | Pride
Crc colorectal cancer machine learning maldi msi matrix assisted laser desorption/ionisation mass spectrometry imaging 
ProteomicsCancer tissue classification using machine learning applied to MALDI MSI and high resolution H&E stained images
Aim is to identify a panel of m/z markers for the early detection of colorectal cancer (CRC). Identification of a molecular pattern that can distin- guish the primary tumours of colorectal cancer with lymph node metastasis compared to those without. Materials and Methods: Using MALDI MSI data, we de...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD019666 | Pride
Crc colorectal cancer machine learning maldi msi matrix assisted laser desorption/ionisation mass spectrometry imaging 
ProteomicsNGLY1 deficiency perturbs cerebral development by affecting stress tolerability and neural stem cell signaling during neurogenesis
Although NGLY1 deficiency has been discovered as a result of mutations in the NGLY1 gene, cellular and molecular mechanisms underlying the neurological abnormalities due to NGLY1 malfunction in the brain remain mostly unknown. Using human cerebral organoid (CO) models and systems biology techniques,...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD026681 | Pride
Neurodevelopment Neuroprogenitors Stress responses Ngly1 Secretory factors Congenital deglycosylation disorder Cerebral organoids Human pluripotent stem cells 
ProteomicsUncovering tumor-stroma inter-relationships using quantitative MALDI-Mass spectrometry imaging
To facilitate analysis of protein expression changes in in situ tumors and stroma, we took advantage of a mouse model that permits conditional activation of the Ser-Thr kinase ROCK within mammary tumor cells. In this study, we undertook MALDI-MSI analysis of tissue samples derived from our condition...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-07 | PXD019255 | Pride
Breast cancer Trafficking Extra-cellular matrix Stroma Maldi imaging 
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