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TranscriptomicsExpression changes after loss of Dot1l in murine MLL-AF9 leukemia cells
MLL-fusions may induce leukemogenic gene expression programs by recruiting the histone H3K79 methyltransferase to MLL-target promoters. We evaluated gene expression changes after cre-mediated loss of Dot1l in leukemia cells obtained from mice injected with MLL-9 transformed lineage negative bone mar...
ORGANISM(S): Mus musculus 
2011-09-12 | E-GEOD-25911 | biostudies-arrayexpress
TranscriptomicsEfficacy of cyclin-dependent-kinase 9 inhibitors in a murine model of mixed lineage leukemia
MLLENL transformed primary cells were treated for 6h with 250nM flavopiridol, PC585 or DMSO as control. RNA was isolated and analyzed on Agilent SurePrint G3 Mouse GE 8x60K (Agilent Microarray Design ID 028005) arrays.
ORGANISM(S): Mus musculus 
2014-07-22 | E-MEXP-3978 | biostudies-arrayexpress
ProteomicsZNF384 fusion oncoproteins drive lineage aberrancy in acute leukemia
ZNF384-rearranged fusion oncoproteins (FO) define a subset of lineage ambiguous leukemias, but the mechanistic role of ZNF384 FO in leukemogenesis and lineage ambiguity is poorly understood. Here, using viral expression in mouse and human hematopoietic stem and progenitor cells (HSPCs) and a Ep300-Z...
ORGANISM(S): Homo sapiens (Human) 
2022-03-16 | PXD028481 | Pride
Znf384 Stem cell Leukemia Fusion oncoprotein Lineage ambiguous Mixed phenotype 
GenomicsExpression, ChIP-chip, and ChIP-Seq data from REH and SEM leukemia cell lines [ChIP-Seq]
MLL-fusion proteins are potent inducers of cancer in hematopoietic cells, where they are known to cause changes in global gene expression. How MLL-fusion proteins interact with the genome has not been established, so we have limited understanding of the pathway by which these proteins generate aberr...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-38338 | biostudies-arrayexpress
GenomicsEpigenetic profiling of hematopoietic stem cells and leukemia stem cells
The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations that involve the Mixed Lineage Leukemia (MLL) gene. We identified the MLL-fusion targets in a murine MLL-AF9 leukemia model, and conducted epigenetic profiling for H3K7...
ORGANISM(S): Mus musculus 
2011-09-13 | E-GEOD-29130 | biostudies-arrayexpress
GenomicsAutomated CUT&Tag profiling of chromatin heterogeneity in mixed-lineage leukemia
Automated CUT&Tag profiling of chromatin heterogeneity in mixed-lineage leukemia
PRJNA669859 | ENA
GenomicsMixed-lineage leukemia cells undergo unique adaptations in the CNS niche
Mixed-lineage leukemia cells undergo unique adaptations in the CNS niche
PRJNA1297052 | ENA
TranscriptomicsRNA-seq data of acute leukemias of ambiguous lineage (ALAL)
We generated RNA-seq data of 30 cases of acute leukemia of ambiguous lineage (ALAL), including both bilineal and biphenotypic patients, in order to develop methods to improve the diagnosis of this disease. First, we used an in-house pipeline to comprehensively detect genetic lesions in RNA-sequencin...
ORGANISM(S): Homo sapiens 
2025-05-16 | E-MTAB-15145 | biostudies-arrayexpress
TranscriptomicsExpression and ChIP-chip data from REH and SEM leukemia cell lines
MLL-fusion proteins are potent inducers of cancer in hematopoietic cells, where they are known to cause changes in global gene expression. How MLL-fusion proteins interact with the genome has not been established, so we have limited understanding of the pathway by which these proteins generate aber...
ORGANISM(S): Homo sapiens 
2008-12-14 | E-GEOD-13313 | biostudies-arrayexpress
GenomicsRole of HRP2 in mixed lineage leukemia compared to its paralog LEDGF/p75
Role of HRP2 in mixed lineage leukemia compared to its paralog LEDGF/p75
PRJNA645412 | ENA
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