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ProteomicsProteomic shift in mouse embryonic fibroblasts Pfa1 during ML210-induced ferroptosis
This report provides data on ferroptosis induced proteomic response in immortalized mouse embryonic fibroblasts which are 4-OH-TAM-inducible Gpx4−/− (referred to as Pfa1 cells). Pfa1 cells are a valuable, widespread and well characterized model for ferroptosis research. We used ML210 (SML0521, Sigma...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-10 | PXD041327 | Pride
Proteomics Mouse embryonic fibroblasts Ferroptosis Ml210 Erastin Glutathione peroxidase 4 Pfa1 Cell death 
UnknownEpithelial-Mesenchymal Transition Suppression by ML210 Enhances Gemcitabine Anti-Tumor Effects on PDAC Cells.
Not available
S-EPMC11763895 | biostudies-literature
UnknownA GPX4-targeted photosensitizer to reverse hypoxia-induced inhibition of ferroptosis for non-small cell lung cancer therapy.
Not available
S-EPMC10466276 | biostudies-literature
UnknownMachine learning approach informs biology of cancer drug response.
Not available
S-EPMC9112473 | biostudies-literature
OtherA genome-wide CRISPR screen identifies mediators of ferroptosis sensitivity in polyunsaturated fatty acid-treated cells
Polyunsaturated fatty acids (PUFA) sensitize cells to ferroptotic cell death. In the study associated with this dataset, we used UACC257 as a model cell line (intrinsically resistant to ferroptosis) induced to be sensitive to ferroptosis with different PUFAs. We performed genome-wide CRISPR knockout...
ORGANISM(S): Homo sapiens 
2020-01-01 | GSE130982 | GEO
OtherA genome-wide CRISPR screen identifies mediators of ferroptosis sensitivity in clear-cell carcinomas
Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies commonly originating in the kidney and ovary. CCC tumors are distinguished by aberrant lipid and glycogen accumulation and are inherently refractory to a broad range of anti-cancer therapies. In the study associa...
ORGANISM(S): Homo sapiens 
2019-03-04 | GSE126696 | GEO
GenomicsA genome-wide CRISPR screen identifies mediators of ferroptosis sensitivity in polyunsaturated fatty acid-treated cells
A genome-wide CRISPR screen identifies mediators of ferroptosis sensitivity in polyunsaturated fatty acid-treated cells
PRJNA542171 | ENA
GenomicsA genome-wide CRISPR screen identifies mediators of ferroptosis sensitivity in clear-cell carcinomas
A genome-wide CRISPR screen identifies mediators of ferroptosis sensitivity in clear-cell carcinomas
PRJNA523003 | ENA
UnknownEnzalutamide inhibits PEX10 function and sensitizes prostate cancer cells to ROS activators.
Not available
S-EPMC11297951 | biostudies-literature
GenomicsNeuroblastoma tumors are sensitive to ferroptosis inducers – GPX4 inhibitors
Neuroblastoma tumors are sensitive to ferroptosis inducers – GPX4 inhibitors
PRJNA1261963 | ENA
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