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ProteomicsDistinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome
Local mRNA translation is required for adaptive changes in the synaptic proteome. The mitogen-activated protein kinase (MAPK) interacting protein kinases 1 and 2 (MNK1 and MNK2) have emerged as key regulators of neuronal translation, primarily through phosphorylation of the eukaryotic initiation fac...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-01 | PXD058409 | Pride
Mnk1 Tmt Synaptoneurosomes Mnk2 
GenomicsRNA-seq of cortical synaptoneurosomes from MNK1 and MNK2 KO mice.
RNA-seq of cortical synaptoneurosomes from MNK1 and MNK2 KO mice.
PRJEB104236 | ENA
UnknownMNK2 governs the macrophage antiinflammatory phenotype.
Not available
S-EPMC7959504 | biostudies-literature
TranscriptomicsRNA-seq of cortical synaptoneurosomes from MNK1 and MNK2 KO mice.
The experiment was designed to study which genes are differentially expressed on mRNA level in MNK1 or MNK2 KO mice, focusing on synaptic compartment, and further correlate these genes with mis-expressed proteins in the same genotype mice. This would reveal whether MNK1 or MNK2 KOs mostly affect tra...
ORGANISM(S): Mus musculus 
2026-02-10 | E-MTAB-16276 | biostudies-arrayexpress
GenomicsPolysome profiling quantified by RNA sequencing in PANC1 cells treated with MNK2 inhibitors or DMSO
Polysome profiling quantified by RNA sequencing in PANC1 cells treated with MNK2 inhibitors or DMSO
PRJNA824788 | ENA
UnknownMNK2 deficiency potentiates β-cell regeneration via translational regulation.
Not available
S-EPMC7613404 | biostudies-literature
TranscriptomicsPolysome profiling quantified by RNA sequencing in PANC1 cells treated with MNK2 inhibitors or DMSO
Regenerating pancreatic b-cells is a potential curative approach for diabetes. We previously identified the small molecule CID661578 as a potent inducer of b-cell regeneration but its target and mechanism of action have remained unknown. We now screened 257 million yeast clones and determined that C...
ORGANISM(S): Homo sapiens 
2022-04-19 | GSE200477 | GEO
UnknownRegulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2.
Not available
S-EPMC2335346 | biostudies-literature
UnknownMNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways.
Not available
S-EPMC4834573 | biostudies-literature
UnknownThe mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.
Not available
S-EPMC86666 | biostudies-literature
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