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ProteomicsBDNF stimulation of protein synthesis in cortical neurons requires the eIF4E kinase Mnk1
Although the Mnks have been known for >15 years, their roles in the regulation of protein synthesis have remained obscure. Here we explore how BDNF stimulates protein synthesis in cortical neurons. Using a combination of pharmacological and genetic approaches, we show that this effect depends on MEK...
ORGANISM(S): Mus musculus (Mouse) 
2014-11-06 | PXD001074 | Pride
Mnk1 Cortical neurons Boncat Mouse Fmrp Silac Bdnf Obitrap elite Eif4e 
ProteomicsDistinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome
Local mRNA translation is required for adaptive changes in the synaptic proteome. The mitogen-activated protein kinase (MAPK) interacting protein kinases 1 and 2 (MNK1 and MNK2) have emerged as key regulators of neuronal translation, primarily through phosphorylation of the eukaryotic initiation fac...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-01 | PXD058409 | Pride
Mnk1 Tmt Synaptoneurosomes Mnk2 
GenomicsRNA-seq of cortical synaptoneurosomes from MNK1 and MNK2 KO mice.
RNA-seq of cortical synaptoneurosomes from MNK1 and MNK2 KO mice.
PRJEB104236 | ENA
GenomicsBlocking tumor-intrinsic MNK1 kinase restricts metabolic adaptation and diminishes liver metastasis
Blocking tumor-intrinsic MNK1 kinase restricts metabolic adaptation and diminishes liver metastasis
PRJNA971725 | ENA
TranscriptomicsRNA-seq of cortical synaptoneurosomes from MNK1 and MNK2 KO mice.
The experiment was designed to study which genes are differentially expressed on mRNA level in MNK1 or MNK2 KO mice, focusing on synaptic compartment, and further correlate these genes with mis-expressed proteins in the same genotype mice. This would reveal whether MNK1 or MNK2 KOs mostly affect tra...
ORGANISM(S): Mus musculus 
2026-02-10 | E-MTAB-16276 | biostudies-arrayexpress
ProteomicsRAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR
Uveal melanoma (UM) is a high fatality cancer. It arises in the eye and spreads (metastasizes) to the liver in 50% of affected patients, with a low survival rate of 5 years. In >85% of patients, their ocular tumors have mutations in specific genes, GNAQ and GNA11, leading to tumor progression and me...
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD068873 | Pride
Uveal melanoma Liver metastasis. Mnk1/2 Rab1a Mtor 
TranscriptomicsBlocking tumor-intrinsic MNK1 kinase restricts metabolic adaptation and diminishes liver metastasis
To investigate the functions of tumor cell-intrinsic MNK1 kinase, we used CRISPR/Cas9 to generate two MNK1 knockout 4T1 cell lines (sg-MKNK1-1 and sg-MKNK1-2). We then performed gene expression profiling analysis using data obtained from RNA-seq, comparing each sg-MKNK1 4T1 cell line to a wild-type ...
ORGANISM(S): Mus musculus 
2024-11-11 | GSE232359 | GEO
GenomicsExtensive pre-clinical validation of an anti-MNK1 aptamer capable of targeting pancreatic ductal adenocarcinoma cancer stem cells
Preclinical validation of an anti-MNK1 aptamer targeting pancreatic cancer stem cells
PRJEB94044 | ENA
UnknownMnk1/2 kinases regulate memory and autism-related behaviours via Syngap1.
Not available
S-EPMC10411928 | biostudies-literature
UnknownBlocking tumor-intrinsic MNK1 kinase restricts metabolic adaptation and diminishes liver metastasis.
Not available
S-EPMC11397505 | biostudies-literature
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