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UnknownEvaluation of the in vitro activity of ceftaroline, ceftazidime/avibactam and comparator antimicrobial agents against clinical isolates from paediatric patients in Kuwait: ATLAS data 2012–19
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S-EPMC8648167 | biostudies-literature
TranscriptomicsTranscription profiling of human embryonic kidney cells overexpressing SMYD2 to identify which genes are regulated by SMYD2 through its histone lysine methylation activity
Identification of SMYD2 target genes - The objective of this aim is to identify which genes are regulated by SMYD2 through its histone lysine methylation activity. It is well established that post-translational modification of nucleosomal histones (H2A, H2B, H3 and H4), such as methylation, acetyla...
ORGANISM(S): Homo sapiens 
2008-02-05 | E-MEXP-963 | biostudies-arrayexpress
TranscriptomicsUnder conditions of hormonal adjuvant treatment the estrogen receptor apoprotein supports breast cancer cell cycling through the retinoic acid receptor M-NM-11 apoprotein
Under conditions of hormonal adjuvant treatment the estrogen receptor apoprotein supports breast cancer cell cycling through the retinoic acid receptor M-NM-11 apoprotein. Basal proliferation persisted in estrogen-sensitive breast cancer cells grown in hormone depleted conditioned media without or w...
ORGANISM(S): Homo sapiens 
2011-05-13 | E-GEOD-26298 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cell types after 24 hrs serum starvation
Comparison of cell types after 24 hrs serum starvation.
ORGANISM(S): Homo sapiens 
2006-05-01 | E-MEXP-519 | biostudies-arrayexpress
TranscriptomicsDrug-inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites
Plasmodium and Toxoplasma are parasites of major medical importance that belong to the Apicomplexa phylum of protozoa. These parasites transform into various stages during their life cycle and express a specific set of proteins at each stage. Although still little is known of how gene expression is ...
ORGANISM(S): Toxoplasma gondii 
2010-06-21 | E-GEOD-15241 | biostudies-arrayexpress
TranscriptomicsOTX2 drives medulloblastoma proliferation via direct regulation of cell cycle genes and inhibits differentiation
The transcription factor OTX2 has been implicated as an oncogene in medulloblastoma, which is the most common malignant brain tumor in children. It is highly expressed in most medulloblastomas and amplified in a subset of them. The role of OTX2 in medulloblastoma and its downstream targets are uncle...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-22875 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of lung cancer cells transfected with scrambled siRNA and siRNA targeting the ETS2 gene
ETS2 is a canonical transcriptional factor and member of the ETS family of genes. ETS2 binds to consensus ERE binding sites in a broad spectrum of genes thus affecting many intracellular molecular functions. However, the role of ETS2 in the biology and pathogenesis of lung cancers is still not known...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-43459 | biostudies-arrayexpress
TranscriptomicsA Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasitophorous vacuole. During infection, Toxoplasma actively remodels the transcriptome of its hosting cells with profound and coupled impact on the host immune response. ...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-38782 | biostudies-arrayexpress
TranscriptomicsHost cell subversion by Toxoplasma GRA16, a HAUSP- and PP2A-interacting protein exported to the host cell nucleus
Toxoplasma gondii multiplies inside a parasitophorous vacuole in the host cell. Several parasite proteins have been described that hijack host signaling pathways, which mostly originate from the rhoptry organelles. We report here the identification and characterization of GRA16, the first dense gran...
ORGANISM(S): Homo sapiens 
2013-02-06 | E-GEOD-38779 | biostudies-arrayexpress
TranscriptomicsAnalysis of allele specific expression and its chromatin state to identify genes that are escaping X chromosome inactivation
Disappearance of the Barr body has long been considered a hallmark of cancer, although whether this corresponds to epigenetic instability and transcriptional reactivation, or to genetic loss, has remained unclear. Here we show that in breast cancer cell lines as well as primary breast tumors, the in...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-62966 | biostudies-arrayexpress
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