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TranscriptomicsmiRNA profiling of Macaca mulatta intact duodenum samples following chronic Delta9 Tetrahydrocannabinol (M-NM-^T9-THC) treatment to SIV infected rhesus macaques
The study describes miRNA expression in intact duodenum following chronic delta 9 tetrahydrocannabinol (M-NM-^T9-THC) administration to SIV-infected rhesus macaques. Chronic M-NM-^T9-THC administration to uninfected macaques significantly and positively modulated intestinal miRNA expression by incre...
ORGANISM(S): Macaca mulatta 
2014-11-19 | E-GEOD-61654 | biostudies-arrayexpress
TranscriptomicsIdentification of target genes regulated by M-NM-^TNp63M-NM-1 in SaOS-2 cells stably expressed with M-NM-^TNp63M-NM-1
To identify the target gene of M-NM-^TNp63M-NM-1, in osteosarcoma cells, we performed the global gene expression profiling in SaOS- 2 cells stably overexpressing the M-NM-^TNp63M-NM-1 gene (SaOS- 2-M-NM-^TNp63M-NM-1). M-NM-^TNp63M-NM-1 target genes were identified by comparison with genes expressed...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-54942 | biostudies-arrayexpress
ProteomicsMudPIT analyses of FLAG-DYRK1A and FLAG-Controls affinity-purified from cytoplasmic extracts of HEK293 cells
Approximately 10E9 cells for each cell line (FLAG-DYRK1A, FLAG-DYRK1A-K188R, and FLAG-controls) were collected and washed with PBS. Cells were swollen for 15 minutes in hypertonic buffer (Buffer A: 10 mM Hepes pH 7.9, 1.5 mM MgCl2, 10 mM KCl, 0.5 mM DTT) freshly supplemented with protease inhibitor ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-23 | MSV000085815 | MassIVE
TranscriptomicsRNA-Seq anlalysis of prostate cancer cell lines using Next Generation Sequencing
Beginning with precursor lesions, aberrant DNA methylation marks the entire spectrum of prostate cancer progression. We mapped the global DNA methylation patterns in selected prostate tissues and cell lines using Methylplex-Next Generation Sequencing (M-NGS). Hidden Markov Model based next generatio...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-29155 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of Macaca mulatta intact colon samples during acute SIV infection
This study describes differential miRNA expression in intact colon tissue during acute SIV infection of rhesus macaques. Nine miRNAs were found to be significantly affected by infection, with 5 down-regulated and 4 up-regulated miRNAs. The expression of one upregulated miRNA was further characterize...
ORGANISM(S): Macaca mulatta 
2014-06-01 | E-GEOD-56624 | biostudies-arrayexpress
TranscriptomicsmiRNA expression changes in small intestinal lamina propria leukocyte samples during the course of SIV infection of rhesus macaques
This study describes differential miRNA expression in small intestinal lamina propria leukocyte samples longitudinally during the course of SIV infection of rhesus macaques. Notably, the T-cell activation associated miR-15b, miR-142-3p, miR-142-5p and miR-150 expression was significantly downregulat...
ORGANISM(S): Macaca mulatta 
2016-02-29 | E-GEOD-77134 | biostudies-arrayexpress
UnknownPLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway.
Not available
S-EPMC6558801 | biostudies-literature
TranscriptomicsTranscriptomics analysis of human of stage specific atherosclerotic plaques: Signature mRNA-miRNA profile of disease severity (mRNA data)
Detection of the altered expression of inflammation associated genes in patients’ blood can provide information regarding the stage of atherosclerotic plaque without undergoing invasive procedures. In the current study, the expression levels of mRNAs within the early stage and advanced stage atheros...
ORGANISM(S): Homo sapiens 
2021-06-01 | E-MTAB-10052 | biostudies-arrayexpress
GenomicsGenome wide DNA methylation sequencing of ischemic skeletal muscle from normal, hyperlipidemic and type 2 diabetic mice
Objective: To define the role of epigenetics, particularly DNA methylation in adaptive vascular growth in hyperlipidemic and type 2 diabetic mouse models of hind limb ischemia Methods: Unilateral hindlimb ischemia was induced by ligating femoral artery proximal to the bifurcation of superficial and ...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-42092 | biostudies-arrayexpress
TranscriptomicsAn epigenetic mark of polycomb response elements implemented by Trx/MLL/COMPASS
In Drosophila, Polycomb Response Elements (PREs) are identified as genomic sequences allowing the maintenance of transcriptional repression in the absence of the initiating signal. Although PREs in Drosophila are well characterized, the existence of mammalian PRE-like elements remains debated. Accu...
ORGANISM(S): Homo sapiens 
2016-07-26 | E-GEOD-81795 | biostudies-arrayexpress
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