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ProteomicsVisualization of lysosomal membrane proteins by cryo-electron tomography
Dysfunction in lysosomal membrane proteins and their associated complexes impairs the lysosome's essential role as a key signaling hub within the cell. This disruption underlies severe neurological disorders, such as lysosomal storage diseases and cancer. While direct visualization of the proteomic ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-17 | PXD055923 | Pride
Lysosomes Lysosomal storage disorders Cryo-electron tomografy Protein structures 
ProteomicsTRPV2 ion channel interactome reveals functional interaction with NCAM and L1CAM in neurite outgrowth
TRPV2 voltage-insensitive, calcium-permeable ion channels play important roles in cancer progression, immune response, and neuronal development. Despite TRPV2’s physiological impact, underlying endogenous proteins mediating TRPV2 responses and affected signaling pathways remain elusive. Using quanti...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD048282 | Pride
Neurite outgrowth Trpv2 Neural cell adhesion molecule (ncam) L1cam 
ProteomicsTRPV2 ion channel interactome reveals functional interaction with NCAM and L1CAM in neurite outgrowth
TRPV2 voltage-insensitive, calcium-permeable ion channels play important roles in cancer progression, immune response, and neuronal development. Despite TRPV2’s physiological impact, underlying endogenous proteins mediating TRPV2 responses and affected signaling pathways remain elusive. Using quanti...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-14 | PXD048260 | Pride
Neurite outgrowth Trpv2 Neural cell adhesion molecule (ncam) L1cam 
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