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TranscriptomicsRheumatoid arthritis and anti-TNF treatment
In 15 patients with rheumatoid arthritis the baseline expression (t=0) of type I IFN-regulated genes was determined in peripheral blood cells (PAXgene) using cDNA-microarrays and compared to levels one month after (t=1) anti-TNF treatment (infliximab). Therefore, we used 43K cDNA microarrays from th...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-19821 | biostudies-arrayexpress
ProteomicsProteomic analysis of nonsmall cell lung cancer
These data correspond to PMID: 22761400, "In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers." (Mol Cell Proteomics. 2012 Oct;11(10):916-32. Epub 2012 Jul 3.)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2013-11-18 | MSV000078491 | MassIVE
TranscriptomicsExpression data from progesterone receptor knockout versus heterozygous mouse oviducts
The oviducts play a critical role in gamete and embryo transport, as well as supporting fertilization and early embryo development. Progesterone receptor (PGR) is a transcription factor highly expressed in oviductal cells, while it’s activating ligand, progesterone (P4), surges to peak levels as ...
ORGANISM(S): Mus musculus 
2014-06-16 | E-GEOD-51499 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profiling of CML and normal quiescent cells.
Chronic myeloid leukaemia (CML) is a clonal haemopoietic stem cell (HSC) disorder associated with the BCR-ABL oncogene, which encodes a constitutively active tyrosine kinase. We have demonstrated the existence of CML HSC which are resistant to the tyrosine kinase inhibitors (TKI). We have hypothesis...
ORGANISM(S): Homo sapiens 
2018-01-12 | E-MTAB-3220 | biostudies-arrayexpress
ProteomicsMulti-omics revealed molecular mechanisms underlying guard cell systemic acquired resistance
Systemic Acquired Resistance (SAR) as a plant immune response improves immunity of distal tissue after local exposure to a pathogen. Stomata pores on leaf surfaces are formed by guard cells that recognize bacterial pathogens via pattern recognition receptors. We found that Arabidopsis thaliana plant...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-09-09 | PXD022880 | Pride
Fatty acid Immunity Guard cell Redox Multi-omics Systemic acquired resistance 
ProteomicsIdentification of DIR1-dependant cellular responses required for systemic acquired resistance in guard cells
After localized invasion by bacterial pathogens, systemic acquired resistance (SAR) is induced in uninfected plant tissues, resulting in enhanced defense against a broad range of pathogens. Although SAR requires mobilization of signaling molecules via the plant vasculature, the specific mechanisms r...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-17 | PXD024991 | Pride
Proteomics Arabidopsis thaliana Guard cells Lipidomics Metabolomics 
ProteomicsArabidopsis thaliana Col-0 pgm1 spsa1 highlight and chilling temperatures proteins LC-MS/MS
Abiotic stress exposure of plants induces metabolic reprogramming which is tightly regulated by signalling cascades connecting transcriptional with translational and metabolic regulation. Complexity of such interconnected metabolic networks impedes the functional understanding of molecular plant str...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-11-06 | PXD010580 | Pride
Arabidopsis thaliana Spsa1 Abiotic stress Metabolic reprogramming  mass spectrometry  machine learning Combined stress Pgm1 
ProteomicsProteome Analysis of AAV producing HEK293 cells
Adeno-associated viral (AAV) vectors are widely used for gene therapy, providing treatment for diseases caused by absent or defective genes. Despite the success of gene therapy, AAV-manufacturing is still challenging, with production yields being limited. With increased patient demand, improvements ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-09 | PXD028154 | Pride
Hek293 Proteomics Gene therapy Aav Lc-ms/ms Label free 
MetabolomicsCDK4/6 inhibitor-mediated cell overgrowth triggers an osmotic stress response and chronic p38MAPK activation to promote long-term cell cycle arrest

Cell size and the cell cycle are intrinsically coupled and abnormal increases in cell size are associated with senescence and permanent cell cycle arrest. The mechanism by which overgrowth primes cells to withdraw from the cell cycle remains unknown. We investigate this here using CDK4/6 inhibito...

2025-10-24 | MTBLS5868 | MetaboLights
MetabolomicsCell overgrowth potentiates osmotic and replication stresses to promote p38/p53/p21-dependent senescence
Abnormal increases in cell size are associated with senescence and cell cycle exit. The mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain unknown. We address this question using CDK4/6 inhibitors, which arrest cells in G0/G1 and are licensed to treat advanced HR+/HER...
2025-10-24 | MTBLS8698 | MetaboLights
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