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ProteomicsTandem affinity purification of monobodies against STAT3
The aim of the proteomics experiment was to determine the specificity of the generated monobodies for the target protein STAT3. This was done in an affinity-enrichment experiment using two endogenously expressed and tandem-affinity-tagged monobodies in two different cell lines (Jurkat and K562). Elu...
ORGANISM(S): Homo sapiens (Human) 
2020-07-10 | PXD018374 | Pride
Monobody Stat3 Tap Lc-ms/ms 
ProteomicsDevelopment of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase
Mirror-image proteins, composed of D-amino acids, are an attractive therapeutic modality, as they exhibit high metabolic stability and lack immunogenicity. Development of mirror-image binding proteins is achieved through chemical synthesis of D-target proteins, phage display library selection of L-b...
ORGANISM(S): Homo sapiens (Human) 
2024-10-28 | PXD056009 | Pride
Monobodies Oncogenic bcr::abl1 kinase Mirror-image-monobodies 
UnknownMonobodies as enabling tools for structural and mechanistic biology.
Not available
S-EPMC7370805 | biostudies-literature
UnknownDevelopment of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase.
Not available
S-EPMC11666773 | biostudies-literature
UnknownAllosteric modulation of a human protein kinase with monobodies.
Not available
S-EPMC6628680 | biostudies-literature
UnknownEngineering Calreticulin-Targeting Monobodies to Detect Immunogenic Cell Death in Cancer Chemotherapy.
Not available
S-EPMC8200062 | biostudies-literature
UnknownSelective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
Not available
S-EPMC5417323 | biostudies-literature
UnknownFN3-based monobodies selective for the receptor binding domain of the SARS-CoV-2 spike protein.
Not available
S-EPMC7863792 | biostudies-literature
UnknownCytosolic delivery of monobodies using the bacterial type III secretion system inhibits oncogenic BCR: ABL1 signaling.
Not available
S-EPMC11483992 | biostudies-literature
UnknownSelective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains.
Not available
S-EPMC7431413 | biostudies-literature
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