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ProteomicsMolecular surface mimicry enables CRBN to target G3BP2 for degradation
Molecular glue degraders (MGDs) are small molecule compounds that repurpose the ubiquitin-proteasome system to induce degradation of challenging therapeutic targets. Thalidomide-analogs are clinically effective MGDs that bind cereblon (CRBN), a substrate receptor of the Cullin-4/RING E3 ubiquitin li...
ORGANISM(S): Homo sapiens (Human) 
2026-01-14 | PXD064243 | Pride
Targeted protein degradation Monte rosa therapeutics G3bp2 Crbn Molecular glue 
ProteomicsA degron-mimicking molecular glue drives CRBN homo-dimerization and degradation
Cereblon (CRBN) is a ubiquitin ligase widely harnessed for targeted protein degradation. We report the discovery of a molecular glue that drives CRBN homo-dimerization and subsequent fast, potent, and selective CRBN degradation by the ubiquitin proteasome system. The structure of the complex reveals...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD060544 | Pride
Human Jurkat Dia Timstof ultra Crbn 
ProteomicsA degron-mimicking molecular glue drives CRBN homo-dimerization and degradation
Cereblon (CRBN) is a ubiquitin ligase widely harnessed for targeted protein degradation. We report the discovery of a molecular glue that drives CRBN homo-dimerization and subsequent fast, potent, and selective CRBN degradation by the ubiquitin proteasome system. The structure of the complex reveals...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD060261 | Pride
Homo sapiens Tmt Orbitrap eclipse Dda 
ProteomicsA degron-mimicking molecular glue drives CRBN homo-dimerization and degradation
Cereblon (CRBN) is a ubiquitin ligase widely harnessed for targeted protein degradation. We report the discovery of a molecular glue that drives CRBN homo-dimerization and subsequent fast, potent, and selective CRBN degradation by the ubiquitin proteasome system. The structure of the complex reveals...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-08 | PXD065335 | Pride
Dda Tmt Orbitrap eclipse J774a.1 cells Mus musculus (mouse) 
UnknownA degron-mimicking molecular glue drives CRBN homo-dimerization and degradation.
Not available
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S-EPMC10542332 | biostudies-literature
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