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UnknownR-α-Lipoic Acid and 4-Phenylbutyric Acid Have Distinct Hypolipidemic Mechanisms in Hepatic Cells.
Not available
S-EPMC7460023 | biostudies-literature
ProteomicsIdentification of regulators of polyploidization presents therapeutic targetsfor treatment of AMKL
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Go...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-01-27 | MSV000078536 | MassIVE
UnknownActivation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid.
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S-EPMC4547883 | biostudies-literature
TranscriptomicsCharacterization of genome-wide transcriptional changes in liver and adipose tissues of ZDF (fa/fa) rats fed R-α-lipoic acid by next-generation sequencing
We report on the characterization of lipogenic tissue transcriptional networks that support physiological responses of obese rats to a lipid-lowering bioactive food compound, R-a-lipoic acid (LA). Nine-week old male ZDF (fa/fa) rats were fed a chow diet supplemented with 3 g LA per kg diet or pair f...
ORGANISM(S): Rattus norvegicus 
2014-01-08 | E-GEOD-50424 | biostudies-arrayexpress
UnknownR-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.
Not available
S-EPMC3311522 | biostudies-literature
UnknownSuperiority of the Triple-Acting 5-HT6R/5-HT3R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT6R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats.
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S-EPMC10641814 | biostudies-literature
TranscriptomicsSingle-cell copy number varation detection
Detection of genomic rearrangements from a single cell instead of a population of cells is an emerging research technique with important applications in the study of human fertility, constitutional chromosomal disorders, and tumor progression. Here, we develop a method to improve the detection of si...
ORGANISM(S): Homo sapiens 
2011-08-23 | E-GEOD-27892 | biostudies-arrayexpress
UnknownThe <i>ENTPD1</i> promoter polymorphism -860 A > G (rs3814159) is associated with increased gene transcription, protein expression, CD39/NTPDase1 enzymatic activity, and thromboembolism risk.
Not available
S-EPMC6137499 | biostudies-literature
ProteomicsLoss of Rnd3/RhoE induces entosis in human hepatocellular carcinoma
Entosis is a process that leads to the formation of cell-in-cell structures commonly found in cancers. Here, we identified entosis in hepatocellular carcinoma and the loss of Rnd3 as an efficient inducer of this mechanism. We characterized the different stages and the molecular regulators of entosis...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043640 | Pride
Rnd3 Rhoa/rock Lamp-1 Hepatocellular carcinoma Cell-in-cell Entosis Tumor progression. 
UnknownMethicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.
Not available
S-EPMC3248012 | biostudies-literature
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