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ProteomicsProteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in lifespan extension C4PR_LIV
Dietary restriction (DR) has been shown to increase lifespan in organisms ranging from yeast to mammals. This suggests that the underlying mechanisms may be evolutionarily conserved. Indeed, upstream signalling pathways, such as TOR, are strongly linked to DR-induced longevity in various organisms. ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-17 | PXD025004 | Pride
Mitochondria Chaperone Calorie restriction Saccharomyces cerevisiae Aging 
ProteomicsProximity labelling reveals effects of disease-causing mutations on the DNAJC5/cysteine string protein α interactome
Cysteine string protein α (CSPα), also known as DNAJC5, is a member of the DnaJ/Hsp40 family of co-chaperones. The name derives from a cysteine-rich domain, palmitoylation of which enables localization to intracellular membranes, notably neuronal synaptic vesicles. Mutations in the DNAJC5 gene that ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-04 | PXD037258 | Pride
Exocytosis Neuronal ceroid lipofuscinosis Warwick_rtp Miniturbo Snare Pc12 cell Neurodegeneration Stxbp1 
UnknownExploring doctors' perspectives on generative-AI and diagnostic-decision-support systems.
Not available
S-EPMC12306348 | biostudies-literature
UnknownContext-specific, evidence-based planning for scale-up of family planning services to increase progress to MDG 5: health systems research.
Not available
S-EPMC3563623 | biostudies-literature
TranscriptomicsExpression data from ozone-treated wild-type and G-protein null mutant Arabidopsis lines
Ozone pollution decreases plant growth and yield worldwide. Some of the effects are genetically-mediated and are reported to involve G-protein signaling pathways. Effects of ozone on gene expression were examined in wild-type and G-protein null mutants to determine affected genes and to determine ...
ORGANISM(S): Arabidopsis thaliana 
2011-12-24 | E-GEOD-34667 | biostudies-arrayexpress
UnknownNatural Language Processing markers in first episode psychosis and people at clinical high-risk.
Not available
S-EPMC8669009 | biostudies-literature
TranscriptomicsIllumina Infinium HumanMethylation450 BeadChip profiling of paediatric high grade gliomas from the HERBY clinical trial
We have used Illumina Infinium HumanMethylation450 BeadChip array profiling to profile paediatric high grade gliomas within the HERBY clinical trial. The HERBY trial was a phase-II open-label, randomised, multicentre trial evaluating bevacizumab in patients with newly-diagnosed non-brainstem HGG bet...
ORGANISM(S): Homo sapiens 
2018-05-11 | E-MTAB-5552 | biostudies-arrayexpress
UnknownThe modeled distribution of corals and sponges surrounding the Salas y Gomez and Nazca ridges with implications for high seas conservation.
Not available
S-EPMC8475544 | biostudies-literature
UnknownOffspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass.
Not available
S-EPMC6471519 | biostudies-literature
TranscriptomicsSystems analysis of the Merck Ad5/HIV vaccine reveals robust induction of a core innate immune gene network: in vivo analysis
Here we applied a systems approach to define human innate immune signatures following MRKAd5/HIV immunization and to analyze the effects of pre-existing Ad5 immunity. We defined the global early immune response to MRKAd5/HIV by profiling the PBMC transcriptomes from seven Ad5Neg individuals pre- and...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-22768 | biostudies-arrayexpress
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