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MetabolomicsMetabolic differences in ripening of Solanum lycopersicum 'Ailsa Craig' and three monogenic mutants
Application of mass spectrometry enables the detection of metabolic differences between groups of related organisms. Differences in the metabolic fingerprints of wild-type Solanum lycopersicum and three monogenic mutants, ripening inhibitor (rin), non-ripening (nor) and Colourless non-ripening (Cnr)...
2014-02-07 | MTBLS36 | MetaboLights
ProteomicsDevelopmental mRNA clearance by PIWI-bound endo-siRNAs in Paramecium
The clearance of untranslated mRNAs by Argonaute proteins is essential for embryonic development in metazoans. However, it is currently unknown whether a similar process exists in unicellular eukaryotes. The ciliate Paramecium tetraurelia harbors a vast array of Argonaute proteins of the Piwi-clade ...
ORGANISM(S): Paramecium tetraurelia 
2023-05-10 | PXD038984 | Pride
Paramecium tetraurelia Piwi Mrna clearance Untranslated mrna Total protein < 25kda Sirnas 
UnknownModeling MyD88 Deficiency In Vitro Provides New Insights in Its Function.
Not available
S-EPMC7786022 | biostudies-literature
TranscriptomicsRNA-seq of mouse alveolar macrophages from control and Influenza A virus infected animals
Based on the observations that influenza infection led to behavioral changes in alveolar macrophages (AMs), we performed an RNAseq experiment to delineate global gene expression changes that occurred in the AM population after influenza infection versus a control (non-infected) population.
ORGANISM(S): Mus musculus 
2020-08-31 | E-MTAB-9429 | biostudies-arrayexpress
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
UnknownNon-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial.
Not available
S-EPMC11108781 | biostudies-literature
ProteomicsIdentification of regenerating island-derived protein 3E in dogs
Our aim was to identify Regenerating islet-derived (REG proteins in dogs. We annotated REG-family members in the canine genome and proteome, and identified one member of the REG3 subfamily, consequently termed REG3E by the Vertebrate Gene Nomenclature Committee. We verified REG3E gene expression usi...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-10-17 | PXD035694 | Pride
Gastrointestinal Biomarker Sepsis Canine Pancreatitis Canis lupus familiaris Pancreas 
ProteomicsSuboptimal codon pairs trigger ribosome collisions and cellular quality control responses in tRNA modification mutants
Validation of activation of RQC in U34 tRNA modification mutants by identification of ubiquitination of ribosomal proteins uS3 and uS10.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-12-29 | PXD066757 | Pride
Trna modification  ribosome profiling  protein aggregates  protein homeostasis  ribosome-associated quality control  chaperones  integrated stress response  mrna translation  codon pairs  codon optimality 
ProteomicsCharacterisation of the Semliki Forest Virus-host cell interactome reveals the viral capsid protein as an inhibitor of nonsense-mediated mRNA decay
Understanding the complex interactions between the viral and the host cell proteins is crucial for elucidating the mechanisms underlying successful virus replication strategies and for developing specific antiviral interventions. This project presents the first comprehensive protein-protein interact...
ORGANISM(S): Homo sapiens (Human) Semliki Forest virus 
2021-05-07 | PXD022036 | Pride
Semliki forest virus  sfv  capsid  sirna screen  alphavirus  rna virus  nmd  virus-host protein interactions Nonsense-mediated mrna decay 
UnknownGenome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
Not available
S-EPMC6218410 | biostudies-literature
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