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ProteomicsmTPP of temperature sensitive proteasome mutants
Temperature sensitive (TS) missense mutants have been foundational in the characterization essential gene function. However, an unbiased approach for the analysis of the biochemical and biophysical changes in TS missense mutants within the context of their functional proteomes is lacking. We applied...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-11-03 | PXD017222 | Pride
Tpp Yeast Proteasome Lc-ms/ms 
TranscriptomicsCharacterization of extended transcripts by RNA-Seq suggests that Rrp6 influences Nrd1-dependent termination
RNAPII is responsible for transcription of protein-coding genes and short, regulatory RNAs. In Saccharomyces cerevisiae, termination of RNAPII-transcribed RNAs ≤1000 bases requires the NNS complex (comprised of Nrd1, Nab3, and Sen1) processing by the exosome, and the nuclear specific catalytic subun...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-14 | E-GEOD-57155 | biostudies-arrayexpress
ProteomicsFACT, PAF-C, and CKII
Protein-protein interaction analysis for RNA Polymerase II and its elongation factors including: the PAF Complex, the FACT Complex, casein kinase II, DSIF, and TFIIF. These studies also characterized a number of casein kinase II phosphorylation sites on the subunits of the PAF Complex.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2015-07-20 | MSV000079197 | MassIVE
ProteomicsCharacterization of the redox proteome in Drosophila melanogaster aging eyes.
During oxidative stress, reactive oxygen species (ROS) can modify and damage cellular proteins. In particular, the thiol groups of cysteine residues can undergo reversible or irreversible oxidative post-translation modifications (PTMs). Identifying the redox-sensitive cysteines on a proteome-wide sc...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-04-27 | PXD036110 | Pride
Drosophila eye Oxidative post-translation modifications Redox proteome Aging 
ProteomicsCryo-EM Structures of Prion protein filaments from Gerstmann-Sträussler-Scheinker disease
Aggregation of the prion protein (PrP) and formation of PrP amyloid (APrP) is severe in some Prion diseases. In the dominantly inherited prion protein amyloidosis known as Gerstmann-Sträussler-Scheinker (GSS) disease, plaques made of PrP amyloid are a distinct feature. The TTC to TCC mutation in Pr...
ORGANISM(S): Homo sapiens (Human) 
2022-07-18 | PXD032402 | Pride
Cryo-em structures of prion protein filaments from gerstmann-sträussler-scheinker disease 
ProteomicsMechanisms associated with systemic effects of cancer
Cancer is considered as a disease of a specific organ, but its effects are felt throughout the body. The systemic effects of cancer can lead to weakness in muscles and heart, which hastens cancer-associated death. The majority of preclinical studies, including our own, on cancer-induced skeletal mus...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD034000 | Pride
Breast cancer Muscle stem cells Skeletal muscle Lc-msms. Mir-486 Cancer cell line Human Biomarker 
ProteomicsProteomic Analyses of Plasma from Patients with Fracture Related Infection Reveals Systemic Activation of the Complement and Coagulation Cascades
Patients/Participants: Twenty-seven patients meeting confirmatory FRI criteria were matched to 27 controls based on fracture region, age, and time after surgery Intervention: Tandem Mass Tag (TMT) LC-MS analysis of patient plasma samples Main Outcome Measurements: Abundances for over 1000 proteins w...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-15 | MSV000093116 | MassIVE
ProteomicsHypusine Biosynthesis in β Cells Links Polyamine Metabolism to Facultative Cellular Proliferation to Maintain Glucose Homeostasis
Deoxyhypusine synthase (DHPS) utilizes the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly-defined mechanisms. Because germline deletion of Dhps is embryonically lethal, its role in normal postnatal cellular fun...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD015424 | Pride
Polyamines Β cell Hypusine Proliferation 
Proteomics: Hypusine Biosynthesis in β Cells Links Polyamine Metabolism to Facultative Cellular Proliferation to Maintain Glucose Homeostasis
: Deoxyhypusine synthase (DHPS) utilizes the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly-defined mechanisms. Because germline deletion of Dhps is embryonically lethal, its role in normal postnatal cellular f...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015414 | Pride
Polyamines Β cell Hypusine Proliferation 
ProteomicsSuccinyl-CoA synthetase deficiency in mouse forebrain results in hyper-succinylation with perturbed neuronal transcriptional regulation and metabolism
Lysine-succinylation is a subtype of protein acylation associated with metabolic regulation of succinyl-CoA in the TCA cycle. Deficiency of succinyl-CoA synthetase (SCS), the TCA-cycle enzyme catalyzing the reversible conversion of succinyl-CoA to succinate, leads to mitochondrial encephalomyopathy ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-06-21 | MSV000089697 | MassIVE
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