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ProteomicsIsolation and characterization of multi-protein complexes enriched in the K-Cl co-transporter 2 from brain plasma membranes
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanism neurons use to regulate its membrane trafficking, stability and activity are ill-defined. To address these issues, we used affinity purification to isolate stable multi-protein complexes of...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-22 | PXD021368 | Pride
Kcc2 Phosphorylation Proteome Interactome 
ProteomicsSpectrin-beta 2 facilitates the selective accumulation of GABAA receptors at somatodendritic synapses
Fast synaptic inhibition is dependent on targeting specific GABAAR subtypes to dendritic and axon initial segment (AIS) synapses. Synaptic GABAARs are typically assembled from 1-3, and subunits. Here, we isolate distinct GABAARs from the brain and interrogate their composition using quantitative pr...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD038703 | Pride
Ais Gaba a receptors Spectrins 
ProteomicsComparative proteome analysis across moss, monocots and dicots unveils the evolutionary dynamics of core processes
Comparative functional genomics offers a powerful approach to study species evolution. To date, the majority of these studies have focused on the transcriptome in mammalian and yeast phylogenies. Here we present a novel multi-species proteomic dataset and a computational pipeline to compare the prot...
ORGANISM(S): Physcomitrella patens subsp. patens (Moss) Solanum tuberosum (Potato) Arabidopsis thaliana (Mouse-ear cress) Zea mays (Maize) Medicago truncatula (Barrel medic) (Medicago tribuloides) Oryza sativa (Rice) Pinus taeda 
2020-11-04 | PXD013606 | Pride
Lc-ms/ms Plants Phylogeny Dda 
ProteomicsThe PDE4 inhibitor apremilast modulates ethanol responses in Gabrb1 S409A knock-in mice via PKA-dependent and independent mechanisms
We previously showed that the PDE4 inhibitor apremilast reduces ethanol consumption in mice by protein kinase A (PKA) and GABAergic mechanisms. Preventing PKA phosphorylation of GABAA 3 subunits partially blocked apremilast-mediated decreases in alcohol drinking. Here, we produced Gabrb1-S409A knock...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-06 | PXD052839 | Pride
Gaba a receptor Mutany Apremilast Pka Gabrb1 Ethanol 
ProteomicsStudying the role of LMTK3 in the brain
Studying the phosphorylation events related to LMTK3 and its associated proteins in the brain. LMTK3 appears to be associated with the excitatory and inhibitory synaptic machinery, therefore this study was carried out to examine it's role in modulating inhibitory synapses.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-05-22 | PXD050212 | Pride
Synapse Phosphorylation Gaba Mouse Lmtk3 Brain 
ProteomicsThe one hour human proteome: Orbitrap Astral Mass Spectrometer
We highlight the leap in performance made possible with new instrumentation in the Thermo Scientific Orbitrap Astral™ mass spectrometer. Integrated alongside a high-resolution accurate mass (HRAM) Orbitrap analyzer, the instrument introduces a fast-switching quadrupole mass filter congruent with dow...
ORGANISM(S): Homo sapiens (Human) 
2024-03-29 | PXD049028 | Pride
Proteomics Dia Orbitrap astral High-throughput 
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
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