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ProteomicsAcute stress induces long-term metabolic, functional and structural remodeling of the heart
Takotsubo syndrome is a stress-induced cardiomyopathy with symptoms comparable to those of acute coronary syndrome but without coronary obstruction. Initially considered spontaneously reversible, the reversibility of takotsubo was challenged by epidemiological studies showing high morbi-mortality in...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-28 | PXD032667 | Pride
Tims tof pro Mouse heart takotsubo model Label-free quantification Stress-induced cardiomyopathy 
UnknownPhase dependent sympathetic dysinnervation in Takotsubo syndrome revealed with transparent heart.
Not available
S-EPMC11947107 | biostudies-literature
TranscriptomicsNeutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice
Neutrophil abscess formation is critical in innate immunity against many pathogens. Here, the mechanism of neutrophil abscess formation was investigated using a mouse model of Staphylococcus aureus cutaneous infection. Gene expression analysis of S. aureus-infected skin revealed that induction of ne...
ORGANISM(S): Mus musculus 
2012-12-05 | E-GEOD-36826 | biostudies-arrayexpress
TranscriptomicsUSR_template_replicates
Next-generation sequencing (NGS) of antibody variable regions has emerged as a powerful tool in systems immunology by providing quantitative molecular information on polyclonal humoral immune responses. Reproducible and robust information on antibody repertoires is valuable for basic and applied imm...
ORGANISM(S): Mus musculus 
2013-10-26 | E-MTAB-1896 | biostudies-arrayexpress
TranscriptomicsASC deficiency suppresses proliferation and prevents medulloblastoma incidence
Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is silenced by promoter methylation in many types of tumors, yet ASC’s role in most cancers remains unknown. Here, we show that ASC is highly expressed in a model of medulloblastoma, the most common malignant pedi...
ORGANISM(S): Mus musculus 
2014-05-23 | E-GEOD-48682 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of FACS sorted mouse calvarial osteroblasts at defined differentiation stages to identify genes highly associated with osteoblast differentiation
This study compares a comprehensive microarray analysis of unsorted mCOB cultures at two level of cell differentiation with cells that are more homogeneous for a level of cellular differentiation. It demonstrates the loss of information and in some cases misinformation that occurs when a heterogeneo...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2332 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells
Upon encounter with antigen, mature B cells undergo complex changes in their physiological state and anatomical localization, and initiate a differentiation process that ultimately produces antibody-secreting cells (ASCs), a major effector population of the immune system. To better characterize this...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-60927 | biostudies-arrayexpress
MetabolomicsNLRP3 Senses L-Arginine to Inhibit Inflammasome Activation and Alleviate Parkinson’s disease Pathology

We screened a series of metabolites and found that L-Arg strongly inhibits NLRP3 inflammasome assembly in vitro. Mechanistically, L-Arg directly binds the D31 site of NLRP3, blocking NLRP3-ASC interaction and subsequent inflammasome assembly. This discovery establishes NLRP3 as a direct sensor fo...

2026-09-02 | MTBLS13737 | MetaboLights
GenomicsWe describe a method to culture organoids from adult human kidney tissue and describe applications for the culture system.
Adult Stem Cell (ASC)-derived organoids are 3D epithelial structures that recapitulate essential aspects of their organ of origin. We have developed conditions for the long-term growth of primary kidney epithelial organoids. Cultures can be established from mouse and human kidney tissue, as well as ...
EGAS00001002729 | EGA
TranscriptomicsExamination of whole genome gene expression profiles of two chicken breeds
We report the genome-wide DNA methylation mapping of chicken by methylated DNA immunoprecipitation following by highthroughput sequencing, and the gene expression profile of chicken by RNA-seq. For meDIP-seq, about 17,202,074 to 27,501,760 reads were generated for the tissue and liver tissues of the...
ORGANISM(S): Gallus gallus 
2010-04-02 | E-GEOD-21169 | biostudies-arrayexpress
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