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TranscriptomicsMolecular Profiling of the Developing Axial Skeleton: A role for Tgfbr2 in the Development of the Intervertebral Disc.
This SuperSeries is composed of the following subset Series: GSE18647: Gene expression in embryonic intervertebral disc and vertebrae. GSE18648: TGF-beta and BMP mediated gene expression in cultured sclerotome. Refer to individual Series
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18649 | biostudies-arrayexpress
TranscriptomicsGene expression in embryonic intervertebral disc and vertebrae.
Very little is known about how intervertebral disc (IVD) is formed or maintained. Members of the TGF-ß superfamily are secreted signaling proteins that regulate many aspects of development including cellular differentiation. We recently showed that deletion of Tgfbr2 in Col2a expressing tissue resul...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18647 | biostudies-arrayexpress
TranscriptomicsDownregulation of miR-760 Causes Human Intervertebral Disc Degeneration by Targeting the MyD88/Nuclear Factor-Kappa B Signaling Pathway
Dysregulation of microRNAs (miRNAs) plays a critical role in the development of intervertebral disc degeneration (IDD). In this study, we present evidence from in vitro and in vivo research to elucidate the mechanism underlying the role of miR-760 in IDD. miRNA microarray and quantitative reverse tr...
ORGANISM(S): Homo sapiens 
2022-03-17 | E-MTAB-11554 | biostudies-arrayexpress
TranscriptomicsLS001A: Aging/Early Degeneration Of The Intervertebral Disc Involves Downregulation Of Canonical Wnt Signaling and Caveolin-1 expression
Objective: Aging and early degeneration of the intervertebral disc (IVD) involves the substition of notochordal cells (NCs) in the nucleus pulposus (NP) by chondrocyte-like cells (CLCs). This study investigated the gene expression profiles involved in this process using NP tissue from both non-chond...
ORGANISM(S): Canis lupus familiaris 
2013-01-31 | E-GEOD-35717 | biostudies-arrayexpress
ProteomicsAn efficient extraction of intervertebral disc (IVD) proteins coupled with the Liquid chromatography-tandem mass spectrometry (LC-MS/MS) detection
A specific discovery proteomic protocol for intervertebral discs relies on an efficient protein extraction using the bead beating homogenizing method with stainless steel grinding balls coupled with a customized lysis buffer, and followed by the protein detection with specific mass spectrometry sett...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-11 | PXD015033 | Pride
Extraction Intervertebral disc Lc-ms 
TranscriptomicsTGF-beta and BMP mediated gene expression in cultured sclerotome.
Very little is known about how intervertebral disc (IVD) is formed or maintained. Members of the TGF-beta superfamily are secreted signaling proteins that regulate many aspects of development including cellular differentiation. We recently showed that deletion of Tgfbr2 in Col2a expressing tissue re...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18648 | biostudies-arrayexpress
ProteomicsSM/J mice display spontaneous early onset disc degeneration link to ion transport system and matrisome changes
To fully apprehend the complex mechanisms responsible for intervertebral disc (IVD) degeneration, one needs to gain a deeper understanding of what characterizes a good and bad intervertebral disc. Using a quantitative proteomic approach, we compared methodically the differences existing between a mo...
ORGANISM(S): Mus musculus (Mouse) 
2018-04-16 | PXD008784 | Pride
Mouse intervertebral disc Nucleus pulposus Lg/j and sm/j. Proteomic 
ProteomicsProteomic landscape of murine intervertebral disc reveals mechanisms involved in homeostasis and disc structure maintenance
To fully apprehend the complex mechanisms responsible for intervertebral disc (IVD) degeneration, one needs to gain a deeper understanding of what characterizes a healthy disc. Using a quantitative proteomic approach, we analyzed methodically the differences existing between IVD genders, levels and ...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD006671 | Pride
Mouse intervertebral disc Nucleus pulposus Annulus fibrosus Proteomic Homeostasis Structure maintenance 
TranscriptomicsHuman induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury
We generated iPSCs from human intervertebral disc cells which were obtained during spine fusion surgery of patients with spinal cord injury. The disc cell-derived iPSCs (diPSCs) showed similar characteristics to human embryonic stem cells (hESCs) and were efficiently differentiated into neural proge...
ORGANISM(S): Homo sapiens 
2015-01-15 | E-GEOD-64964 | biostudies-arrayexpress
GenomicsSingle Cell RNA Sequencing of Adult Mouse Intervertebral Disc Cells
Single Cell RNA Sequencing of Adult Mouse Intervertebral Disc Cells
PRJNA985456 | ENA
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