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MetabolomicsUntargeted Metabolomics of Mouse Platelet Pellets by LC-MS/MS
In this study, platelet pellets were isolated from mouse peripheral blood through gradient centrifugation to obtain high-purity platelet samples. Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based untargeted metabolomics was performed to comprehensively profile the global metabolic chan...
2026-08-04 | MTBLS15244 | MetaboLights
TranscriptomicsTranscription profiling of human platelets from patients with essential thrombocythemia
Human blood platelets have important, regulatory functions in diverse hemostatic and pathological disorders, including vascular remodeling, inflammation, and wound repair. Microarray analysis was used to study the molecular basis of essential thrombocythemia, a myeloproliferative disorder with quant...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-2006 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse bone marrow lineage- c-Kit+ Sca-1+ cells in which floxed Mpl alleles were specifically and homozygously deleted in megakaryocytes and platelets
Thrombopoietin (TPO) acting via its receptor Mpl is the major cytokine regulator of platelet number. To precisely define the role of specific hematopoietic cells in TPO dependent hematopoiesis, we generated mice that express the Mpl receptor normally on stem/progenitor cells but lack expression on m...
ORGANISM(S): Mus musculus 
2014-06-10 | E-MTAB-2389 | biostudies-arrayexpress
TranscriptomicsDirect Signaling Between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis
Interactions of cancer cells with the primary tumor microenvironment are important determinants of cancer progression towards metastasis but it is unknown whether additional prometastatic signals are provided during the intravascular transit to the site of metastasis. Here, we show that transient pl...
ORGANISM(S): Mus musculus 
2011-12-13 | E-GEOD-27456 | biostudies-arrayexpress
TranscriptomicsRNA-seq shows genes enhanced in translation and transcription pathways in MKs and platelets from Slfn14fl/flPF4-Cre mouse model
To identify the mechanism through which SLFN14 may regulate megakaryopoiesis and platelet function, we performed RNA sequencing analysis to define alterations in gene activity arising as a result of conditionally knocking down Slfn14 in vivo. Bulk RNA-sequencing was performed on total RNA extracted ...
ORGANISM(S): Mus musculus 
2025-09-29 | E-MTAB-15572 | biostudies-arrayexpress
ProteomicsAcetylated proteomic identification of stored platelets
In this project, the protein acetylation levels in human platelets and in WT and SIRT3-/- mouse platelets during storage were examined.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-06-09 | PXD026341 | Pride
Stored platelets  acetylation  sirt3 
TranscriptomicsIGR_Raslova_LMMC
Characterization of genetic alterations in monocoyte lineage (CD14+ cells) of two CMML (Chronicle Myelo-Monocytic Leukemia) patients. Previously we have shown that RUNX1 downregulates MYH10 expression in megacaryocyte lineage leading in MYH10 overexpression in platelets of patients wiht RUNX1 geneti...
ORGANISM(S): Homo sapiens 
2013-01-16 | E-MTAB-1121 | biostudies-arrayexpress
TranscriptomicsGene expression profile in platelets of mouse regulated by Smad4 gene
Mutations of SMAD family member 4 (Smad4) gene caused Hereditary Hemorrhagic Telangiectasia (HHT). It was believed that bleeding disorders were caused by arteriovenous malformation in this syndrome. Although several studies indicated dysfunction of platelets from HHT patient, the role(s) of smad4 in...
ORGANISM(S): Mus musculus 
2013-01-29 | E-GEOD-43814 | biostudies-arrayexpress
TranscriptomicsSpecific Inflammatory Stimuli Lead to Distinct Platelet Responses in mice and Humans
Different inflammatory stimuli contribute to the formation of atherosclerosis. It is hypothesized that although the end result is the same - plaque formation in arterial vessels - the pathogenesis is dependent on the etiology. In particular, platelets will respond differently depending on the inflam...
ORGANISM(S): Mus musculus 
2016-05-13 | E-GEOD-68835 | biostudies-arrayexpress
TranscriptomicsExpression profiling of platelets from young (3 months) homozygous Jak2 R1063H mice and wild-type controls
Patients with myeloproliferative neoplasms (MPN), are known to be at an elevated risk for thrombosis but the mechanism for MPN-related coagulation activation is not yet fully characterized. While increased hematocrit has been re-evaluated as a contributing factor, additional mechanisms such as chron...
ORGANISM(S): Mus musculus 
2025-08-22 | E-MTAB-14685 | biostudies-arrayexpress
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