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ProteomicsThe Comprehensive Mouse Retina PhosphoProteome
Diverse groups of proteins play integral roles in both the physiology and pathophysiology of the mouse retina. A comprehensive mouse retina phosphoproteome has been developed using a discovery-based proteomic approach in conjunction with an enrichment procedure for phosphopeptides.
ORGANISM(S): Mus musculus (Mouse) 
2019-02-16 | PXD009981 | Pride
Mouse retina proteome Phosphoproteome Swiss-webster nd4 
ProteomicsThe Comprehensive Mouse Retina Proteome
A comprehensive mouse retina proteome including six development stages (E13.5, E15.5, P0, P6, and P21, mixed sample).
ORGANISM(S): Mus musculus (Mouse) 
2021-07-11 | PXD023439 | Pride
Retina Mouse Lc-ms/ms 
ProteomicsProteomic profiling of embryonic retina to facilitate ocular disease gene discovery
To expedite gene discovery in eye development and its associated defects, we previously developed a bioinformatics resource-tool iSyTE (integrated Systems Tool for Eye gene discovery). However, iSyTE is presently limited to lens tissue and is predominantly based on transcriptomics datasets. Therefor...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-09 | PXD039490 | Pride
Gene discovery Proteome Embryogenesis Retina Mass spectrometry Isyte Development 
ProteomicsThe Comprehensive Mouse Retina Proteome
Diverse groups of proteins play integral roles in both the physiology and pathophysiology of the mouse retina. A comprehensive mouse retina proteome has been developed using a discovery-based proteomic approach.
ORGANISM(S): Mus musculus (Mouse) 
2019-02-16 | PXD009909 | Pride
Mouse retina proteome Swiss-webster nd4 
ProteomicsHigh-pH Reversed-Phase Fractionated Neural Retina Proteome of Normal Growing C57BL/6 Mouse
Mouse was sacrificed at postnatal day 46 by cervical dislocation. Retina were prepared seamlessly with suspension trap (S-TRAP) followed by high-pH reversed-phase peptide fractionation. Peptides fractions were identified with data-dependent acquisition by quadrupole time-of-flight mass spectrometry.
ORGANISM(S): Mus musculus (Mouse) 
2019-09-11 | PXD014459 | Pride
Mass spectrometry Retina Mouse Proteomics 
ProteomicsFirst identification of ITM2B interactome in the human retina
ITM2B is a type II ubiquitous transmembrane protein which role remains unclear. ITM2B mutations have been associated with different disorders: mutations leading to longer mutant proteins have been reported in two distinct Alzheimer-like autosomal dominant disorders with early-onset progressive demen...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020088 | Pride
Ap-ms Human Itm2b Retina Interactome 
ProteomicsIdentification of PKC-alpha dependent phosphoproteins in mouse retina
Adjusting to a wide range of light intensities is an essential feature of retinal rod bipolar cell (RBC) function, and persuasive evidence suggests this modulation involves phosphorylation by protein kinase C-alpha (PKC-alpha). PKC-alpha is a serine/threonine kinase that is strongly expressed in RBC...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-15 | PXD012906 | Pride
Mouse Isobaric labeling Protein kinase c-alpha Quantitative proteomics Signaling Retina 
ProteomicsProbing the Molecular Phenotype of the Transgenerational Ischemia-Resilient Retina
A comparative analysis of the proteome of mouse retina with and without ischemic injury and hypoxia conditioning was achieved through discovery-based quantitative proteomics. Retina from each mouse were harvested immediately for Quantitative Discovery-Based Proteomic Workflow. A 10plex TMT experimen...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD014769 | Pride
Retina mouse ischemia hypoxia tmt quantitative proteomics 
ProteomicsGenetic context modulates aging and degeneration in the murine retina
This is the proteomics component of a multi-omics analysis of the aging murine retina. Age is a critical risk factor for vision-threatening retinopathies. Susceptibility to age-related retinal neurodegeneration is genetically influenced, however, no studies have addressed molecular retinal aging sig...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-23 | PXD057861 | Pride
Genetic diversity Proteomics Retinal vascular disease Tmt Wsb Retinitis pigmentosa Nzo Aging Retina Diabetic retinopathy Lc-ms/ms 
ProteomicsProteome analysis of the retina from RhoQ344X/+ mouse
Retinal proteomes from wild-type and RhoQ344X mutant mice at postnatal day 35 were analyzed by label-free quantitative proteomics to understand proteomic change caused by the rhodopsin mutation.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-11-08 | MSV000093339 | MassIVE
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