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ProteomicsHigh-throughput plasma/serum proteomics by coupling nanoparticle protein corona-based sample preparation and capillary zone electrophoresis-tandem mass spectrometry
A high-throughput workflow for bottom-up proteomics (BUP) of human plasma using capillary zone electrophoresis-tandem mass spectrometry (CZE-MS/MS) and nanoparticle protein corona-assisted sample preparation is presented. The streamlined approach enabled the identification and quantification of hun...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-08-04 | PXD063043 | Pride
Nanoparticle protein corona Bottom-up proteomics High-throughput Cze-ms/ms Biomarker 
ProteomicsIn situ Analysis of Nanoparticle Soft Corona and Dynamic Evolution
How soft corona i.e., the protein corona’s outer layer contributes to “biological” identity of nanomaterials (NMs) is largely unknown due to a longstanding challenge in capturing protein composition of the soft corona in situ. We herein develop an in situ “Fishing” method that can monitor the dynami...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD033976 | Pride
Protein corona Mouse serum 
ProteomicsMechanism of protein corona and surface modification of MSNs affecting the tissue distribution
Once NPs were administered into the physiological condition, several serum proteins could adsorb rapidly onto the NPs to form a protein layer (also called protein corona). The effect of protein corona surrounding the NPs depends on several parameters such as size, charge and other surface properties...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD033783 | Pride
Murine serun proteins Protein corona Msn 
UnknownSurface chemistry and serum type both determine the nanoparticle-protein corona.
Not available
S-EPMC4441341 | biostudies-literature
ProteomicsDiscovering nanoparticle corona ligands responsible for liver macrophage capture
Liver macrophages capture circulating nanoparticles and reduce their delivery to target organs. It is well-known that serum proteins adsorb to the nanoparticle surface after administration. However, the adsorbed serum proteins and their cognate cell receptors for removing nanoparticles from the bloo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-18 | PXD061236 | Pride
Corona Human Serum Mouse Nanoparticle 
TranscriptomicsDevelopmental influence of the cellular prion protein on the gene expression profile in mouse hippocampus
A key event in the pathogenic process of prion diseases is the conversion of the cellular prion protein (PrPC) to an abnormal and protease-resistant isoform (PrPSc). Mice lacking PrP are resistant to prion infection, and down-regulation of PrPC during prion infection prevents neuronal loss and the p...
ORGANISM(S): Mus musculus 
2011-04-12 | E-GEOD-21718 | biostudies-arrayexpress
UnknownHigh-throughput plasma/serum proteomics by coupling nanoparticle protein corona-based sample preparation and capillary zone electrophoresis-tandem mass spectrometry.
Not available
S-EPMC12305297 | biostudies-literature
UnknownUnderstanding the Lipid and Protein Corona Formation on Different Sized Polymeric Nanoparticles.
Not available
S-EPMC6981174 | biostudies-literature
UnknownSurface antibody changes protein corona both in human and mouse serum but not final opsonization and elimination of targeted polymeric nanoparticles.
Not available
S-EPMC10576379 | biostudies-literature
ProteomicsCombining confocal microscopy, dSTORM, and mass spectroscopy to unveil the evolution of the protein corona associated with nanostructured lipid nanocarriers during blood-brain barrier crossing
Upon entering in contact with the biological environment, nanostructures are immediately covered by biomolecules, and in particular proteins forming the so-called “protein corona” (PC). The phenomenon of PC formation has gained great attention in recent years due to its implication for the use of na...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031034 | Pride
Protein corona  blood-brain barrier  lipid nanoparticles  magnetic nanoparticles  super resolution microscopy  dstorm  mass spectroscopy. 
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