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MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15770 | MetaboLights
MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15769 | MetaboLights
ProteomicsMRG15 interactome upon UV irradiation
The aim of this analysis is to identify the difference between interaction partners of MRG15 wild type and Chromodomain and MRG domain mutants upon UV irradiation. Therefore, MRG15 wild type and mutants (N-terminal FLAG tag) were overexpressed in U2OS cells. After UV irradiation, immunoprecipitation...
ORGANISM(S): Homo sapiens (Human) 
2023-07-03 | PXD043089 | Pride
Ner Mrg15 Human 
GenomicsPhase Separation of MRG15 delays cellular senescence [RNA-Seq]
Phase Separation of MRG15 delays cellular senescence [RNA-Seq]
PRJNA1145897 | ENA
GenomicsPhase Separation of MRG15 delays cellular senescence [CUT&Tag]
Phase Separation of MRG15 delays cellular senescence [CUT&Tag]
PRJNA1146141 | ENA
GenomicsIdentification of MRG15 as barrier to somatic reprogramming
Identification of MRG15 as barrier to somatic reprogramming
PRJNA1083950 | ENA
UnknownPhase separation of MRG15 delays cellular senescence.
Not available
S-EPMC12046007 | biostudies-literature
UnknownMRG15 is required for pre-mRNA splicing and spermatogenesis.
Not available
S-EPMC5027415 | biostudies-literature
UnknownMRG15 decline in aged/injured MuSCs hinders regeneration via differentiation defects.
Not available
S-EPMC12831727 | biostudies-literature
GenomicsPhase Separation of MRG15 delays cellular senescence [CUT&Tag]
Phase separation, a biophysical process that segregates subcellular environments into condensates, is recognized for its role in regulating transcription. However, the extent of its influence on cellular senescence processes remains to be fully elucidated. Here, we have established that the depletio...
ORGANISM(S): Homo sapiens 
2025-04-02 | GSE274376 | GEO
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