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MetabolomicsBridging Targeted (Zeno MRM-HR) and Untargeted (SWATH) LC–HRMS in a Single Run for Sensitive Exposomics

Traditionally, chemical exposure has been assessed by low-resolution mass spectrometry via targeted approaches due to the typically extremely low concentration of such compounds in biological samples. Nevertheless, untargeted approaches are now becoming a promising tool for a broader investigatio...

2025-08-28 | MTBLS10565 | MetaboLights
ProteomicsComparison of Protein Expressions of Drug-Metabolizing Enzymes between Human Liver and the Hepatic Cell Lines HepG2, Hep3B and Huh7 using SWATH and MRM-HR Proteomics
Human hepatic cell lines have been widely used as an in vitro model for the study of drug metabolism and liver toxicity. However, the validity of this model is still a subject of debate because the expressions of various proteins including drug-metabolizing enzymes (DMEs) in the cell lines can diffe...
ORGANISM(S): Homo sapiens (Human) 
2018-04-18 | PXD008190 | Pride
Hep3b Swath Human liver Huh7 Mrm-hr Proteomics Drug-metabolizing enzymes Hepg2 Protein expression 
ProteomicsProteomic comparison of epidemic Australian Bordetella pertussis biofilm cells
Bordetella pertussis causes whooping cough, a severe respiratory disease. B. pertussis is a highly genetically homogenous species with only minor levels of genetic variation. It has been shown that single nucleotide polymorphism (SNP) cluster I containing the dominant pertussis toxin promoter allele...
ORGANISM(S): Bordetella pertussis 
2025-09-22 | PXD046513 | Pride
Tmt Bordetella pertussis Mrm-hr Biofilm Lc-ms/ms 
ProteomicsAbsolute Quantitation of All Plasma Proteins from SWATH Data for Biomarker Discovery
The current state of proteomics requires a choice between targeted and discovery methods. The former provides exceptional quantitation and data completeness, but only with few analytes. Discovery proteomics can identify hundreds and thousands of proteins in a sample, but with poor quantitation and...
ORGANISM(S): Homo sapiens (Human) 
2019-01-02 | PXD008234 | Pride
Swath Data-independent acquisition Absolute quantification Plasma biomarkers Lung cancer 
UnknownBridging Targeted (Zeno MRM-HR) and Untargeted (SWATH) LC-HRMS in a Single Run for Sensitive Exposomics.
Not available
S-EPMC11307248 | biostudies-literature
ProteomicsHuman tissue microsomed by MRM, MRMHR and SWATH
The purpose of the present study was to examine simultaneously the absolute protein amounts of 152 membrane and membrane-associated proteins, including 30 metabolizing enzymes and 107 transporters, in pooled microsomal fractions of human liver, kidney and intestine by means of SWATH-MS with stable i...
ORGANISM(S): Homo Sapiens (human) 
2018-01-01 | PXD008265 | JPOST Repository
UnknownComparison of protein expression between human livers and the hepatic cell lines HepG2, Hep3B, and Huh7 using SWATH and MRM-HR proteomics: Focusing on drug-metabolizing enzymes.
Not available
S-EPMC6309175 | biostudies-literature
ProteomicsQuantification of oxidative modification of mouse serum albumin by MRM-HR
After a week of acclimatization, 8-week-old mice were randomly divided into 4 groups consisting of more than 8 mice per group, and subjected to varying total body irradiation (TBI) doses of 0, 0.5, 1 or 3 Gy of X-rays (150 kVp, 20 mA, 0.5-mm aluminum and 0.3-mm copper filters) at a dose rate of 1.0 ...
ORGANISM(S): Mus Musculus (mouse) 
2022-05-12 | PXD025949 | JPOST Repository
ProteomicsPlasma Proteomics Analysis of Human Host Response to Loa Loa, Validation
Loiasis, caused by the filarial nematode Loa loa, imposes a significant burden of disease in endemic regions in West and Central Africa. Manifestations include microfilaria in the blood (MF) and migration of the adult eye worm (EW), with clinical presentations ranging from asymptomatic infections to...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD063487 | Pride
Ms Plasma Proteomics Ntd 
ProteomicsTargeted proteomic analysis of aqueous humor in idiopathic uveitis and Vogt-Koyanagi-Harada syndrome
Extreme gradient boosting (XGBoost), an efficient and robust machine learning algorithm, was used to develop a model for classifying the IU, VKH, and control groups. The three proteins deemed most important were transferrin (TF), calsyntenin-1 (CLSTN1), and retinol-binding protein 4 (RBP4), which re...
ORGANISM(S): Homo Sapiens 
2023-07-06 | PXD043575 |
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