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TranscriptomicsPDE-4 inhibition alters gene expression and improves INH-mediated clearance of Mtb in rabbit lungs
Tuberculosis kills nearly 2 million people through out the world, every year. The outcome of M. tuberculosis infection is determined by the host and bacterial factors. A strong host immune response controls the growth of the bacilli effectively. However, in a host with suboptimal immune response,...
ORGANISM(S): Oryctolagus cuniculus 
2011-03-16 | E-GEOD-27992 | biostudies-arrayexpress
TranscriptomicsEarly innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits
In our rabbit model of pulmonary tuberculosis, infection with Mtb HN878, a hyper-virulent W-Beijing strain, results in progressive cavitary disease. However, infection of rabbit lungs with Mtb CDC1551, a hyper-immunogenic strain is effectively controlled overtime, establishing latent Mtb infection....
ORGANISM(S): Oryctolagus cuniculus 
2013-08-17 | E-GEOD-49947 | biostudies-arrayexpress
TranscriptomicsIdentification of latent tuberculosis infection-related microRNAs in human U937 macrophages expressing Mycobacterium tuberculosis Hsp16.3
Latent tuberculosis infection (LTBI) relies on a homeostasis of macrophages and Mycobacterium tuberculosis (Mtb). The small heat shock protein, Mtb Hsp16.3 (also known as latency-associated antigen), plays an important role in Mtb persistence within macrophages. However, the mechanism of LTBI remain...
ORGANISM(S): Homo sapiens 
2014-03-17 | E-GEOD-54630 | biostudies-arrayexpress
TranscriptomicsEffect of PDE4 inhibition on host gene expression of Mtb-infected mouse lungs.
Global gene expressions of Mtb-infected mouse lungs were compared between with and without PDE4 inhibitor treatment. A lot of host genes are differentially expressed 21d and 28d post-Mtb infection. PDE4 inhibitor, however, downregulate 10% of genes among those and genes differentially regulated by...
ORGANISM(S): Mus musculus 
2010-11-13 | E-GEOD-25313 | biostudies-arrayexpress
TranscriptomicsmiRNA profile of THP-1 macrophage infected with different MTB strains
We examined the microRNA profiles of THP-1 macrophages upon the MTB infection of (1) Beijing/W and non-Beijing/W clinical strains, and (2) susceptible and multidrug-resistant (MDR-) MTB strains. THP-1 cells were induced differentiation into a macrophage phenotype. Then cells were infected with three...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-65811 | biostudies-arrayexpress
ProteomicsTHP-1 macrophage ubiquitinome after Mtb infection
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), capable of manipulating and circumventing the host's immune system to establish infection. Ubiquitination plays a crucial role in the host's response to pathogens; however, the global alterations in protein ubiquitination ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD063016 | Pride
Ubiquitinome Thp-1 macrophage Mycobacterium tuberculosis infection 
MetabolomicsMultiplatform, non-targeted analysis of lung extracts of uninfected and Mtb-infected C57BL/6 mice at 4 and 9 weeks p.i.
Not available
ORGANISM(S): Mus musculus 
ST001328 | MetabolomicsWorkbench
MetabolomicsMultiple acyl-coA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection

The human pathogen Mycobacterium tuberculosis (Mtb) devotes a significant fraction of its genome to fatty acid metabolism. Although Mtb depends on host fatty acids as a carbon source, fatty acid b-oxidation is mediated by genetically redundant enzymes, which has hampered the development of antitu...

2021-09-29 | MTBLS2374 | MetaboLights
TranscriptomicsHost directed activity of Pyrazinamide in Mycobacterium tuberculosis infection
Pyrazinamide (PZA) is one of the first line antibiotics used for the treatment of tuberculosis (TB). we have used human monocyte and a mouse model of pulmonary TB to investigate whether treatment with PZA, in addition to its known anti-mycobacterial properties, modulate the host immune response dur...
ORGANISM(S): Mus musculus 
2013-06-28 | E-GEOD-48027 | biostudies-arrayexpress
TranscriptomicsTime-dependent global gene expression profile of RAW264.7 cells infected with Mycobacterium tuberculosis H37Rv (Mtb)
Transcriptional profiling of RAW264.7 cells infected with M. tuberculosis H37Rv at an MOI of 10 performed 4 and 24 hours post-infection. RAW264.7 cells were infected with Mtb for 4 hours at an MOI of 10. Cells were washed and treated with gentamycin for 2 hours in order to remove adhered bacteria. I...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-64427 | biostudies-arrayexpress
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