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ProteomicsLONP1 and mtHSP70 cooperate to promote mitochondrial protein folding
Because 99% of the mitochondrial proteome is encoded by the nucleus, most mitochondrial precursor polypeptides are imported from the cytosol into the mitochondrion, where they must efficiently fold into their functional state. Mitochondrial precursors are imported as unfolded polypeptides due to th...
ORGANISM(S): Homo sapiens (Human) 
2020-12-07 | PXD021939 | Pride
Aggregates Protein homeostasis Mitochondria Human 
UnknownLONP1 and mtHSP70 cooperate to promote mitochondrial protein folding.
Not available
S-EPMC7801493 | biostudies-literature
UnknownStoichiometric expression of mtHsp40 and mtHsp70 modulates mitochondrial morphology and cristae structure via Opa1L cleavage.
Not available
S-EPMC4462935 | biostudies-literature
UnknownLoss of Function of mtHsp70 Chaperone Variants Leads to Mitochondrial Dysfunction in Congenital Sideroblastic Anemia.
Not available
S-EPMC8888832 | biostudies-literature
UnknownDietary Choline Alleviates High-Fat Diet-Induced Hepatic Lipid Dysregulation via UPRmt Modulated by SIRT3-Mediated mtHSP70 Deacetylation.
Not available
S-EPMC9025889 | biostudies-literature
UnknownMitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex.
Not available
S-EPMC4669791 | biostudies-literature
UnknownMitochondrial proteome disruption in the diabetic heart through targeted epigenetic regulation at the mitochondrial heat shock protein 70 (mtHsp70) nuclear locus.
Not available
S-EPMC5987221 | biostudies-literature
ProteomicsThe mitochondrial Hsp70 controls the assembly of the F1FO-ATP synthase
The mitochondrial F1FO-ATP synthase produces the bulk of cellular ATP. The soluble F1 domain contains the catalytic head that is linked via the central stalk and the peripheral stalk to the membrane embedded rotor of the Fo domain. The assembly of the F1 domain and its linkage to the peripheral stal...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-01-11 | PXD033024 | Pride
Mitochondria F1fo-atp synthase Pulldown Mthsp70 
TranscriptomicsATFS-1 mediates a protective transcription program during mitochondrial stress
ATFS-1 has been shown to regulate transcription of mitochondrial chaperone genes such as mtHsp70/hsp-6 and hsp-60 in response to mitocondrial stress. To identify the entire ATFS-1-mediated response, we compared the transcript profiles from wild-type and atfs-1(tm4525) worms raised in the absence and...
ORGANISM(S): Caenorhabditis elegans 
2012-07-11 | E-GEOD-38196 | biostudies-arrayexpress
UnknownUnderstanding the functional interplay between mammalian mitochondrial Hsp70 chaperone machine components.
Not available
S-EPMC2885226 | biostudies-literature
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