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TranscriptomicsTranscription profiling of two human cellular models of erythroid differentiation: K562 erythroid-leukemia cells treated with 1uM arabinofuranosyl-cytosine (AraC), and CD34+ stem cells treated with 7U/ml erythropoietin
In this study we investigated two cellular models of erythroid differentiation: K562 erythroid-leukemia cells treated with 1uM arabinofuranosyl-cytosine (AraC), and CD34+ stem cells treated with 7U/ml erythropoietin. Time course experiments were performed in both analysed models. Total RNAs were iso...
ORGANISM(S): Homo sapiens 
2006-12-31 | E-MEXP-296 | biostudies-arrayexpress
ProteomicsWhole cell proteome of U2OS cells or Saos-2 cells depleted for SENP3
Ribosome biogenesis is a complex and energy demanding process requiring tight coordination with cell growth and proliferation. Impairment of ribosome biogenesis activates a well-defined cell-cycle checkpoint that primarily relies on the activation of p53 signaling. However, there is mounting evidenc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-28 | PXD037800 | Pride
Sumo Human Senp Lc-ms/ms 
ProteomicsIdentification of SENP3 and SENP5 target proteins by endogenous SUMO2/3 IP-MS
Ribosome biogenesis is a complex and energy demanding process requiring tight coordination with cell growth and proliferation. Impairment of ribosome biogenesis activates a well-defined cell-cycle checkpoint that primarily relies on the activation of p53 signaling. However, there is mounting evidenc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-28 | PXD037793 | Pride
Sumo Human Senp Lc-ms/ms 
ProteomicsIdentification of SENP5 target proteins by endogenous SUMO2/3 IP-MS
Ribosome biogenesis is a complex and energy demanding process requiring tight coordination with cell growth and proliferation. Impairment of ribosome biogenesis activates a well-defined cell-cycle checkpoint that primarily relies on the activation of p53 signaling. However, there is mounting evidenc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-28 | PXD037796 | Pride
Sumo Human Senp Lc-ms/ms 
ProteomicsActionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage Response
The DNA damage response (DDR) acts as a barrier to malignant transformation and is often impaired during tumorigenesis. Exploiting the impaired DDR can be a promising therapeutic strategy; however, the mechanisms of inactivation and corresponding biomarkers are incompletely understood. Starting from...
ORGANISM(S): Homo sapiens (Human) 
2023-07-21 | PXD041851 | Pride
B-cell lymphoma Slf2 Chromatin proteome Dna damage response 
ProteomicsActionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage Response
The DNA damage response (DDR) acts as a barrier to malignant transformation and is often impaired during tumorigenesis. Exploiting the impaired DDR can be a promising therapeutic strategy; however, the mechanisms of inactivation and corresponding biomarkers are incompletely understood. Starting from...
ORGANISM(S): Homo sapiens (Human) 
2023-07-21 | PXD041834 | Pride
B-cell lymphoma Slf2 Dna damage response 
ProteomicsStreptavidin biotin-CCW16 pulldown to determine CCW16-modified proteins in HeLa lysate
The SUMO-targeted E3 ubiquitin ligase RNF4 plays an important role in safeguarding genome and proteome integrity. RNF4 recognizes polySUMO modified proteins and induces their proteolytic or non-proteolytic ubiquitylation. Based on the key functions of RNF4 maintaining proteome and genome stability, ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD056954 | Pride
Ccw16 Targets Hela Lfq Rnf4 
ProteomicsProteomes of chromatin fractions derived from SU-DHL-5 cells
SU-DHL-5 cells display limited expression of the SUMO isopeptidase SENP6. In this experiment, the chromatin associated fraction of SU-DHL-5 cells was analysed by mass spectrometry. SU-DHL-5 cells were either stably transfected with an empty vector or with a SENP6 expression construct. Changes in pro...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027355 | Pride
Su-dhl-5 cells (b-cell lymphoma) 
TranscriptomicsTranscription profiling of Arabidopsis defective in the expression of TGA2, TGA5, and TGA6
12-oxo-phytodienoic acid (OPDA) and phytoprostane A1 (PPA1) are cyclopentenone oxylipins that are formed via the enzymatic; jasmonate pathway and a nonenzymatic, free radical–catalyzed pathway, respectively. Both types of cyclopentenone oxylipins; induce the expression of genes related to detoxifi...
ORGANISM(S): Arabidopsis thaliana 
2008-06-18 | E-GEOD-10732 | biostudies-arrayexpress
TranscriptomicsResponse of Arabidopsis cell culture to phytoprostane A1
12-Oxo-phytodienoic acid (OPDA) and several phytoprostanes are structurally related cyclopentenone oxylipins that can be formed via the enzymatic jasmonate pathway and a non-enzymatic, free radical-catalyzed pathway, respectively. To elucidate the biological activities of phytoprostanes in compariso...
ORGANISM(S): Arabidopsis thaliana 
2008-06-18 | E-GEOD-10719 | biostudies-arrayexpress
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