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ProteomicsIdentification of a novel class of cytotoxic granules as origin of supramolecular attack particles in T lymphocytes
Cytotoxic T lymphocytes (CTL) kill malignant and infected cells via cytotoxic proteins such as granzyme B (GzmB) that are released into the immunological synapse in the form of ~110 nm supramolecular attack particles (SMAPs). However, it is not known where SMAPs are stored in the cell and how they a...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD025055 | Pride
Exocytosis Proteomics Snare proteins Immunological synapse Cytotoxic granules Single core granules Supramolecular attack particles Total internal reflection fluorescence microscopy Correlative light and electron microscopy Multi core granules 
ProteomicsT-cell derived exosomes released from Multi-Core Granules exhibit potent caspase 3 mediated tumor suppressive activity
Small extracellular vesicles (sEV) derived from cytotoxic T lymphocytes (CTLs) are emerging as potential mediators of antitumor immunity, yet their subcellular origins and functional properties remain incompletely defined. In this study, we investigated the intracellular routes and cytotoxic potenti...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD064012 | Pride
Tetraspanins 10x-expansion Munc13-4 Extracellular vesicles Primary cells Cd8+ t-cells Immunological synapse Multivesicular bodies 
ProteomicsT-cell derived exosomes released from Multi-Core Granules exhibit potent caspase 3 mediated tumor suppressive activity ( Part II)
Small extracellular vesicles (sEV) derived from cytotoxic T lymphocytes (CTLs) are emerging as potential mediators of antitumor immunity, yet their subcellular origins and functional properties remain incompletely defined. In this study, we investigated the intracellular routes and cytotoxic potenti...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD070419 | Pride
Tetraspanins 10x-expansion Munc13-4 Extracellular vesicles Primary cells Cd8+ t-cells Immunological synapse Multivesicular bodies 
UnknownT-Cell-Derived Exosomes From Multi Core Granules Exhibit Superior Caspase-3-Mediated Tumor-Suppressive Activity Compared to Those From Multivesicular Bodies.
Not available
S-EPMC12919372 | biostudies-literature
UnknownIdentification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes.
Not available
S-EPMC8873490 | biostudies-literature
UnknownVolume-dependent catalytic efficiency of highly durable Au@Ag-Pt core@multi-shell nanoparticles in methylene blue reduction.
Not available
S-EPMC12642859 | biostudies-literature
Unknown[A systematic pharmacological investigation of pharmacologically active ingredients in Toujie Quwen granules for treatment of COVID-19].
Not available
S-EPMC7429174 | biostudies-literature
MetabolomicsIntegrative Analysis of Trichosanthes kirilowii Maxim Formula Granules’ AntiTriple-Negative Breast Cancer Mechanism via Network Pharmacology, Metabolomics, and Molecular Pharmacology

Background: Triple-negative breast cancer (TNBC) urgently needs effective therapies due to limited targeted options and unfavorable outcomes. We investigated Trichosanthes kirilowii Maxim formula granules (TKM) using integrated network pharmacology, metabolomics, and molecular pharmacology to cla...

2026-02-15 | MTBLS13902 | MetaboLights
TranscriptomicsSpatially resolved multi-bait mapping of stress granule and processing body transcriptome
Stress granules (SGs) are dynamic, membrane-less organelles containing complex RNA-protein networks. The RNA components of SGs have been profiled through various approaches, characterized as long, translation-repressed, and highly epigenetically modified. However, it remains unclear whether these RN...
ORGANISM(S): Homo sapiens 
2024-09-29 | GSE271045 | GEO
UnknownNetwork pharmacology, molecular docking integrated surface plasmon resonance technology reveals the mechanism of Toujie Quwen Granules against coronavirus disease 2019 pneumonia.
Not available
S-EPMC7837196 | biostudies-literature
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